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intestinal stem cells

Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.

Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches

[Cell Stem Cell] Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.

OLFM4-RET Fusion Is an Oncogenic Driver in Small Intestine Adenocarcinoma

[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.

Integrin αEβ7+ T Cells Direct Intestinal Stem Cell Fate Decisions via Adhesion Signaling

[Cell Research] Researchers uncovered a novel role of T cell–stem/transient amplifying cell contact in intestinal stem cell (ISC) fate decisions. They showed that intestinal lymphocyte depletion results in skewed ISC differentiation in mice, which can be rescued by T cell transfer.

Dietary Suppression of MHC Class II Expression in Intestinal Epithelial Cells Enhances Intestinal Tumorigenesis

[Cell Stem Cell] Researchers showed that a high-fat diet reduced the expression of the major histocompatibility complex class II genes in intestinal epithelial cells, including intestinal stem cells.

STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

[Gastroenterology] The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.

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