Tag results:
intestinal stem cells
Intestinal Cell News
Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3
[American Journal of Physiology-Gastrointestinal and Liver Physiology] Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.
Intestinal Cell News
Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches
[Cell Stem Cell] Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.
Intestinal Cell News
OLFM4-RET Fusion Is an Oncogenic Driver in Small Intestine Adenocarcinoma
[Oncogene] Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.
Intestinal Cell News
Integrin αEβ7+ T Cells Direct Intestinal Stem Cell Fate Decisions via Adhesion Signaling
[Cell Research] Researchers uncovered a novel role of T cell–stem/transient amplifying cell contact in intestinal stem cell (ISC) fate decisions. They showed that intestinal lymphocyte depletion results in skewed ISC differentiation in mice, which can be rescued by T cell transfer.
Intestinal Cell News
Dietary Suppression of MHC Class II Expression in Intestinal Epithelial Cells Enhances Intestinal Tumorigenesis
[Cell Stem Cell] Researchers showed that a high-fat diet reduced the expression of the major histocompatibility complex class II genes in intestinal epithelial cells, including intestinal stem cells.
Cancer Stem Cell News
STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism
[Gastroenterology] The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.