intestinal stem cells

[Clinical Gastroenterology and Hepatology] Mouse intestinal organoids and dextran sulfate sodium-induced colitis mouse model were used to assess the effects of recombinant soluble thrombomodulin on proliferation of intestinal epithelial cells.

[Frontiers in Cell and Developmental Biology] Based on the results of a bibliometric analysis of intestinal organoids applications, scientists systematically summarized the latest advances and analyzed the limitations and prospects.

[Cell Reports] Scientists demonstrated that inhibition of a high fat diet (HFD)-activated fatty acid oxidation program created a therapeutic opportunity to counter the effects of a HFD on intestinal stem cells and intestinal tumorigenesis.

[Nature] Apc-mutant intestinal stem cell (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.

[Current Opinion in Cell Biology] The authors review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.

[Cell Stem Cell] Researchers showed that restricted chromatin accessibility in intestinal stem cells prevented the expression of β-Catenin-regulated metabolic enzymes, whereas fine-tuning of WNT/β-Catenin activity by ZNRF3 and RNF43 restricted proliferation in chromatin-permissive AXIN2+ hepatocytes, while preserving metabolic function.