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intestinal stem cells

The Phosphatase PRL-3 Affects Intestinal Homeostasis by Altering the Crypt Cell Composition

[Journal of Molecular Medicine] Researchers employed a doxycycline-inducible phosphatase of regenerating liver-3 (PRL-3) mouse strain to show that aberrant PRL-3 expression within a non-cancerous background led to the death of Lgr5+ intestinal stem cells and to Paneth cell expansion.

BCL-XL Is Crucial for Progression through the Adenoma-to-Carcinoma Sequence of Colorectal Cancer

[Cell Death & Differentiation] By targeting antiapoptotic proteins with specific BH3 mimetics in organoid models of colorectal cancer progression, scientists found that BCL-2 was essential only during instestinal stem cell transformation while MCL1 inhibition did not affect adenoma outgrowth.

Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

[Nature Communications] The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.

High-Fat Diet-Activated Fatty Acid Oxidation Mediates Intestinal Stemness and Tumorigenicity

[Cell Reports] Scientists proposed that a high-fat diet enhanced intestinal stemness and tumorigenicity by engaging a peroxisome proliferator-activated receptor-fatty acid oxidation (PPAR-FAO) program.

RAL GTPases Mediate EGFR-Driven Intestinal Stem Cell Proliferation and Tumorigenesis

[eLife] In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.

NOTUM from Apc-Mutant Cells Biases Clonal Competition to Initiate Cancer

[Nature] Researchers investigated how Apc-mutant cells gain a clonal advantage over wild-type counterparts to achieve fixation and found that Apc-mutant cells were enriched for transcripts that encoded several secreted WNT antagonists, with Notum being the most highly expressed.

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