intestinal stem cells

[Nature Cell Biology] The authors showed that the adult intestinal tracheae are dynamic and respond to enteric infection, oxidative agents and tumors with increased terminal branching.

[Scientific Reports] Using a novel screening method, investigators identified novel transcription factors that regulated the intestinal stem cell fate upon endoplasmic reticulum stress.

[Science Immunology] The authors reported that after distinct types of intestinal epithelial damage, IL-1R1 signaling in GREM1+ mesenchymal cells increased production of R-spondin 3, a Wnt agonist required for intestinal stem cell self-renewal.

[Biology Open] Using the Drosophila midgut as a model, researchers have recently described that adult intestinal stem cells, do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. 

[Stem Cell Reports] The authors showed that the septate junction protein Neuroglian was expressed in intestinal stem cells and enteroblasts within the fly intestine.

[Molecular Cell] Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis.