intestinal stem cells

[Stem Cell Reports] Myh9 deletion disturbs cell junctions and impairs intestinal lumen barrier integrity, promoting the necroptosis of epithelial cells.

[Autophagy] Investigators review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.

[Cellular and Molecular Gastroenterology and Hepatology] Investigators analyzed Lgr5-Cre; APCmin; HER2V777LTg mice by morphologic and gene expression assays on intestinal sections and organoids derived from the epithelium.

[Nature Metabolism] Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.

[iScience] Elevation of Cdc42 activity in young animals by genetic means causes premature ISC aging, whereas pharmacological suppression of elevated Cdc42 activity restores organoid formation potential in vitro.

[Development] By using ex vivo 3D organoid cultures and molecular approaches scientists observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.