ischemic stroke

[Stroke] Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. Researchers found that CHIP was associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.

[European Journal of Neurology] The authors screened the circular RNAs (circRNA) influencing matrix metalloproteinase-9 (MMP9) through the competing endogenous RNA network and evaluated the prognostic value of these circRNAs for acute ischemic stroke.

[Molecular Neurobiology] Due to paucity of standard protocols in extraction procedures of extracellular vesicles (EVs) and their pharmacological properties and mechanisms, the development of new EV dependent therapies is challenging.

[Molecular Psychiatry] The authors describe the current knowledge of the effects of aging on the immune system and the cerebral vasculature and how these changes alter the immune response to stroke and vascular dementia in animal and human studies.

[Experimental Neurology] Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and to investigate the role of neuronal stem cell metabolism in HPC-induced neuroprotection.

[Cell Reports] Investigators reported that AIM protein reduced sterile inflammation by attenuating damage-associated molecular patterns and that AIM administration ameliorated the deleterious effects of ischemic stroke.