islets

[Cell Reports] Scientists created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating over 500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems.

[Pancreas] Adopting a 3D rotary cell culture system, researchers co-cultured several PDAC cell lines and MIN6 islet β cells.

[Cell Reports] MAFAS64F production in male human β cells accelerated cellular senescence and increase senescence-associated secretory proteins compared to cells expressing MAFAWT.

[Acta Biomaterialia] Designing materials to decrease antigen escape, improve cell viability, and increase material compatibility are all approaches that can decrease the local release of antigen and danger signals into the implant microenvironment.

[Journal of Molecular Endocrinology] Scientists investigated the mechanisms underlying the protective role of A20 in the pancreatic beta-cell. Investigators demonstrated a role for A20 in controling beta-cell integrity and survival, which likely resulted from the regulation of inflammatory signaling

[Proceedings of the National Academy of Sciences of the United States of America] Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation is dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes