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islets
Pancreatic Cell News
RNA Aptamers Specific for Transmembrane P24 Trafficking Protein 6 and Clusterin for the Targeted Delivery of Imaging Reagents and RNA Therapeutics to Human β...
[Nature Communications] Researchers reported the identification of two RNA aptamers that specifically and selectively recognize mouse and human β cells.
Pancreatic Cell News
More than Meets the Islet: Aligning Nutrient and Paracrine Inputs with Hormone Secretion in Health and Disease
[American Journal of Physiology-Endocrinology and Metabolism] Investigators critically discuss the contributions of external, intrinsic, and paracrine factors in pancreatic β-, α-, and δ-cell secretion across the full spectrum of physiological (i.e., fasting and fed) and pathophysiological (gluco- and lipotoxicity; diabetes) environments.
Organoid News
HIF-1α Inhibitor PX-478 Preserves Pancreatic β Cell Function in Diabetes
[Science Translational Medicine] In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.
Pancreatic Cell News
Gymnemic Acid Protects Murine Pancreatic β-Cells by Moderating Hyperglycemic Stress-Induced Inflammation and Apoptosis in Type 1 Diabetic Rats
[Journal of Biochemical and Molecular Toxicology] Scientists delineated the role of gymnemic acid in protecting pancreatic β-cells in diabetic animals, with special reference to inflammation and apoptosis.
Pancreatic Cell News
Downregulation of Kcnq1ot1 Attenuates β-Cell Proliferation and Insulin Secretion via the MiR-15b-5p/Ccnd1 and Ccnd2 Axis
[Acta Diabetologica] CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo.
ESC & iPSC News
Lundquist Institute Investigator Dr. Eiji Yoshihara Receives Internationally Prestigious Award for Research on Type 1 Diabetes
[The Lundquist Institute (Cision US, Inc.)] The Lundquist Institute's investigator Dr. Eiji Yoshihara has received a five-year $749,995.50 Career Development Award from the Juvenile Diabetes Research Foundation for his proposed study on how human β cells gain immune evasive function by environmental cues.