Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Possibility of Adiponectin Use to Improve Islet Transplantation Outcomes

In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Microengineered Multi-Organoid System from hiPSCs to Recapitulate Human Liver-Islet Axis in Normal and Type 2 Diabetes

Investigators developed a new microfluidic multi-organoid system that recapitulated the human liver-pancreatic islet axis in normal and disease states.
[Advanced Science]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Researchers Awarded Grant to Study New Method of Islet Transplantation

Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
[Weill Cornell Medicine]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Exposure to Perfluorooctane Sulfonate Reduced Cell Viability and Insulin Release Capacity of β Cells

In a cell-based in vitro bioassay, scientists used mouse β-TC-6 cancer cells and found 48-hour exposure to perfluorooctane sulfonate (PFOS) decreased the cell viability at 50 μmol/L. By measuring insulin content in supernatant, 48-hour pretreatment of PFOS (100 μmol/L) decreased the insulin release capacity of β-TC-6 cells after glucose stimulation.
[Journal of Environmental Sciences]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

SYT8 Promotes Pancreatic Cancer Progression via the TNNI2/ERRα/SIRT1 Signaling Pathway

Synaptotagmin-8 (SYT8) is a membrane protein that regulates hormone secretion and neurotransmission, and its expression is positively regulated by the promoter of the insulin gene in pancreatic islet cells. Researchers identified a previously unknown role of SYT8 in altering tumor characteristics in pancreatic cancer.
[Cell Death Discovery]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Autonomic Control of Pancreatic Beta Cells: What Is Known on the Regulation of Insulin Secretion and Beta-Cell Proliferation in Rodents and Humans

Investigators describe mechanisms involved in insulin secretion as well as metabolic and mitogenic actions on its target tissues.
[Peptides]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Intra-Islet Glucagon Confers β-Cell Glucose Competence for First-Phase Insulin Secretion and Favors GLP-1R Stimulation by Exogenous Glucagon

Researchers reported that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit first phase glucose-stimulated insulin secretion.
[Journal of Biological Chemistry]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Gastrin Producing Syngeneic Mesenchymal Stem Cells Protect Non-obese Diabetic Mice from Type 1 Diabetes

Scientists reported the use of MSCs for the production and delivery of Gastrin, a peptide hormone that is produced by intestinal cells and fetal islets and can increase β-cell mass, to promote protection from type 1 diabetes.
[Autoimmunity]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Intra-Pancreatic Fat Deposition: Bringing Hidden Fat to the Fore

Weight loss-induced decrease of intra-pancreatic fat is tightly associated with remission of type 2 diabetes mellitus and its re-deposition with recurrence of the disease.
[Nature Reviews Gastroenterology & Hepatology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Abnormal Cannabidiol Ameliorates Inflammation Preserving Pancreatic Beta Cells in Mouse Models of Experimental Type 1 Diabetes and Beta Cell Damage

Scientists investigated whether Abn-CBD can modulate the inflammatory response during type 1 diabetes (T1D) onset using a mouse model of T1D and of beta cell damage.
[Biomedicine & Pharmacotherapy]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share
Share