islets

[Cell Reports] Type 1 diabetes (T1D) patients had a lower serum MOTS-c level than did healthy controls. Furthermore, MOTS-c reduced T cell activation by alleviating T cells from the glycolytic stress in T1D patients, suggesting therapeutic potential.

[Journal of Biological Chemistry] Researchers investigated the effects of different doses of metformin on AQP7 expression and explored the possible mechanism of its protective effects in the pancreatic islets.

[Nature Communications] Scientists found that the γ-cell population was heterogeneous, with subsets of cells producing another hormone in addition to pancreatic polypeptide (Ppy).

[American Journal of Physiology-Endocrinology and Metabolism] Cells with the most functional connections tended to activate sooner, have longer active times, and deactivated later. Scientists provided a common ground for recent differing views on beta cell heterogeneity.

[Autophagy] Scientists found that adipose-specific expression of BECN1F121A was sufficient to improve systemic insulin sensitivity without negatively affecting pancreatic insulin storage.

[Acta Diabetologica] Scientists hypothesized that erythropoietin exposure of isolated islets improved their posttransplant revascularization.