islets

[Scientific Reports] Researchers revealed that angiopoietins, including angiopoietin-1 and angiopoietin-2 permitted the generation of islets from iPSCs with elevated glucose responsiveness, a hallmark of mature islets.

[Nature Metabolism] Scientists conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum, from normoglycemia to type 2 diabetes.

[Science Advances] Researchers demonstrated a multilayer hydrogel nanofilm caging strategy capable of protecting cells from high shear stress and reducing immune response by interfering cell-cell interaction.

[JCI Insight] Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass.

[Advanced Science] The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.

[Trends in Endocrinology and Metabolism] Proper material design and biological considerations will improve the success of bioartificial pancreas for regenerative medicine in diabetes.