islets

[Cell Chemical Biology] Investigators showed that basic nitrogen-containing residues blocked central adverse events of Dextromethorphan without reducing its anti-diabetic effects, including the protection of human pancreatic islets from cell death.

[Cell Death & Disease] To search other possible mechanisms, scientists found the mRNA level and protein level of MKP7 (a phosphatase for phospho-JNK) were dramatically reduced in pancreatic β cells in the islets from NR4A1 knockout mice compared with that from wild type mice.

[Journal of Biological Chemistry] Reserachers described and validated the use of the SUnSET approach to demonstrate through FACS and Western Blot that glucose increases protein translation in the human cell line EndoC-βH2

[Scientific Reports] Utilizing Min6 cells, a pancreatic ß-cell model, scientists knocked down G-protein coupled receptor kinase 2 (GRK2) and measured glucose-mediated intracellular calcium responses and insulin secretion.

[Scientific Reports] Islets were kept intact or dispersed into single cells and cultured in the presence of harmine, glucose, or heparin-binding epidermal growth factor-like growth factor (HB-EGF), and subsequently analyzed by immunohistochemistry or flow cytometry.

[Scientific Reports] The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.