Microtubules Regulate Pancreatic β-Cell Heterogeneity via Spatiotemporal Control of Insulin Secretion Hot Spots

Researchers indicate that microtubules (MTs) stability in the β-cell population was heterogenous, and that glucose-stimulated insulin secretion was suppressed in cells with highly stable MTs.
[eLife]
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Cdk5 Drives Formation of Heterogeneous Pancreatic Neuroendocrine Tumors

Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.
[Oncogenesis]
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Implanted Pluripotent Stem-Cell-Derived Pancreatic Endoderm Cells Secrete Glucose-Responsive C-peptide in Patients with Type 1 Diabetes

The authors reported an analysis on one year of data from the first cohort of 15 patients from a single trial site that received subcutaneous implantation of cell products combined with an immunosuppressive regimen.
[Cell Stem Cell]
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In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus

Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.
[ACS Nano]
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Type IIB PKA Is Highly Expressed in β Cells and Controls Cell Proliferation via Regulating Cyclin D1 Expression

Investigators found that the RIIB subunit of protein kinase A is expressed specifically by β cells of mouse and human islets.
[FEBS Journal]
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Aldo-Ketoreductase 1c19 Ablation Does Not Affect Insulin Secretion in Murine Islets

Investigators showed that Akr1c19 expression was dramatically decreased in db/db islets.
[PLoS One]
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Eugenosedin-A Improves Obesity-Related Hyperglycemia by Regulating ATP-Sensitive K+ Channels and Insulin Secretion in Pancreatic β Cells

The authors isolated pancreatic islets from adult male Wistar rats and identified pancreatic β-cells by the cell size, capacitance and membrane potential.
[Biomedicine & Pharmacotherapy]
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Localized Drug Delivery Graphene Bioscaffolds for Cotransplantation of Islets and Mesenchymal Stem Cells

Scientists developed, characterized, and tested an implantable graphene bioscaffold which elutes dexamethasone that could accommodate islets and adipose tissue–derived MSCs.
[Science Advances]
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Microtubules Regulate Pancreatic β Cell Heterogeneity via Spatiotemporal Control of Insulin Secretion Hot Spots

Researchers utilized mouse islets to determine how microtubules affect secretion toward the vascular extracellular matrix at single cell and subcellular levels.
[eLife]
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Lipid Droplets Protect Human β-Cells from Lipotoxicity-Induced Stress and Cell Identity Changes

To obtain insight into the role of lipid droplets (LD) in human islet β-cell function, the levels of a key LD scaffold protein, perilipin 2, were manipulated by lentiviral-mediated knockdown or overexpression in EndoCβH2-Cre cells, a human cell line with adult islet β-like properties.
[Diabetes]
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Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.
[Diabetes]
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