islets

[Scientific Reports] Scientists characterized non-endocrine cells in iPSC-derived pancreatic islet cells using single-cell transcriptomic analysis and found that non-endocrine cells consisted of heterogeneous proliferating cells, and cells with not only pancreatic traits but also liver or intestinal traits marked by FGB or AGR2.

[Nature Biotechnology] Investigators generated functionally mature stem-cell-derived islets using an optimized protocol and benchmarked them comprehensively against primary adult islets.

[Nature Medicine] Researchers achieved high recovery, viability, function and scalability in mouse, porcine, human, and human stem cell-derived beta cell islets by comprehensive optimization of cryoprotectant agent composition, and methods for vitrification and rewarming.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Frontiers in Immunology] The authors used multiplex immunofluorescence imaging analysis to characterize MDA5 expression and distribution in pancreatic tissues obtained from 22 organ donors.

[Journal of Genetics and Genomics] The authors summarize the roles and underlying mechanisms of transcription factors in the maintenance of β-cell identity under physiological and type 2 diabetic conditions.