islets

[Nature Medicine] Porcine and human stem cell-beta islets made insulin in xenotransplant models, and mouse islets tested in a marginal mass syngeneic transplant model cured diabetes in 92% of recipients within 24–48 hours after transplant.

[Scientific Reports] Researchers described that weaning rats fed diets rich in Maillard reaction products were affected in both their immune and endocrine systems.

[Molecular Metabolism] Scientists utilized sorting of physically interacting cells with single-cell RNA-sequencing to systematically map cellular interactions in the endocrine pancreas after pancreatectomy.

[Current Opinion in Pharmacology] Glucagon is often administered to counteract severe hypoglycaemia, and commonly used diabetes medications such as GLP-1 analogues, sulfonylureas and SGLT2-inhibitors also affect alpha cells.

[Stem Cell Reports] Scientists described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.

[Free Radical Biology and Medicine] Researchers investigated whether peri-pancreatic white adipose tissue produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity.