islets

[Nature Metabolism] Scientists provided a single-cell atlas of pancreatic islets of 24 type 1 diabetes, autoantibody-positive and nondiabetic organ donors across multiple quantitative modalities including ~80,000 cells using single-cell transcriptomics, ~7,000,000 cells using cytometry by time of flight and ~1,000,000 cells using in situ imaging mass cytometry.

[European Journal of Pharmaceutical Sciences] Once the main hurdles to stem cell-based therapies are overcome, translation to clinical practice will greatly improve the quality of life of people with type 1 diabetes mellitus.

[Proceedings of the National Academy of Sciences of the United States of America] Using global stimulator of interferon genes (STING) knockout (STING−/−) and β-cell–specific STING knockout (STING-βKO) mouse models, scientists revealed a distinct role of STING in the regulation of glucose homeostasis through peripheral tissues and β-cells.

[Cell Reports] Using four conditional cell lineage tracing murine models, researchers described the natural history of pancreatic islet cells, once they expressed a hormone gene, until late in life.

[Nature Communications] The authors showed that ICl,SWELL and SWELL1 protein were reduced in adipose and β-cells in murine and human diabetes.

[Nature Metabolism] In vitro expression of Mycl provoked active replication in islet cells, even in those from aged mice.