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islets

Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

[Obesity Reviews] Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.

Inter-Organ Crosstalk in Pancreatic Islet Function and Pathology

[Febs Letters] Scientists discuss recent advances in inter-organ communication from the metabolic, immune, and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function, as well as their role in the adaptive responses of islet to nutrition-induced stress.

Organization and Dynamics of the Cortical Complexes Controlling Insulin Secretion in β-Cells

[Journal of Cell Science] Researchers showed that insulin secretion sites also contain non-neuronal proteins LL5β and KANK1, which in migrating cells organize exocytotic machinery in the vicinity of integrin-based adhesions.

ATP Is an Essential Autocrine Factor for Pancreatic β-Cell Signaling and Insulin Secretion

[Physiological Reports] Scientists monitored changes of the intracellular Ca2+ concentration as an immediate read-out for insulin secretion in live cell experiments.

LDB1-Mediated Transcriptional Complexes Are Sensitive to Islet Stress

[Islets] The authors hypothesized that LDB1 and/or ISL1 levels, like other transcriptional regulators, are sensitive to β-cell nutrient and cytokine stresses, likely contributing to β-cell (dys)function under various stimuli.

Possibility of Adiponectin Use to Improve Islet Transplantation Outcomes

[Scientific Reports] In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.

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