Tag Archives: keratinocytes

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Effects of Electrical Stimulation on Human Skin Keratinocyte Growth and the Secretion of Cytokines and Growth Factors

The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.

[Biomedical Materials]

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Construction of a High Fidelity Epidermis-on-a-Chip for Scalable In Vitro Irritation Evaluation

Investigators grew and differentiated human keratinocytes within a microfluidic chip to construct an integrated epidermis-on-a-chip system, which was specially designed to integrate multi-culture units with integrated bubble removal structure.

[Lab On A Chip]

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Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.

[Molecular Medicine Reports]

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Integrin α5β1 Nano-Presentation Regulates Collective Keratinocyte Migration Independent of Substrate Rigidity

The authors used a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels to show that keratinocyte sheets regulated their migration ability at an optimal integrin α5β1 nanospacing.

[eLife]

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EGFR-Mediated Epidermal Stem Cell Motility Drives Skin Regeneration through COL17A1 Proteolysis

Researchers conducted culture experiments that proved epidermal growth factor receptor (EGFR) activation drove human keratinocyte stem cell motility.

[Journal of Cell Biology]

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Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin

By forced expression of the ectodysplasin-A in human epidermal keratinocytes sweat gland (SwG) culture medium, human epidermal keratinocytes were efficiently converted into SwG cells.

[Advanced Science]

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Effect of 1-MHz Ultrasound on the Proinflammatory Interleukin-6 Secretion in Human Keratinocytes

Researchers investigated whether mechanical energy transported by low intensity ultrasound could generate a mechanical stress able to induce the release of inflammatory cytokine such as interleukin-6 in the human keratinocyte cell line, HaCaT.

[Scientific Reports]

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GPCR-Mediated EGFR Transactivation Ameliorates Skin Toxicities Induced by Afatinib

Researchers examined the ability of three different G-protein-coupled receptor (GPCR) agonists to reverse signaling inhibition and ameliorate rash induced by epidermal growth factor receptor inhibitors (EGFRi).

[Acta Pharmacologica Sinica]

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Review

The Current Challenges on Spray-Based Cell Delivery to the Skin Wounds

Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.

[Tissue Engineering Part C-Methods]

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RAS Induced Senescence of Skin Keratinocytes Is Mediated through Rho-Associated Protein Kinase (ROCK)

Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.

[Molecular Carcinogenesis]

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