During 3D organoid formation, the origin of iPS cells affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences]
Radiation with a single dose of 2 Gy not only facilitated fibrosis in cultured human dermal fibroblasts via activation of the Wnt/β-catenin pathway but also initiated EMT in cultured keratinocytes, developing collagen-producing mesenchymal cells.
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Researchers determined if the combination of sevoflurane and adipose-derived stromal cells exerted additional protective effects against acute lung injury induced by cecal ligation and puncture in rats.
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Liang, Z., Zhou, H., Tang, R., Zhang, S., Chen, X., & Pei, L. (2020). Autologous transplantation of adipose-derived stromal cells combined with sevoflurane ameliorates acute lung injury induced by cecal ligation and puncture in rats. Scientific Reports, 10(1), 13760. https://doi.org/10.1038/s41598-020-70767-8 Cite
Investigators proposed that psoriatic keratinocytes transferred miR-381-3p to CD4 + T cells via small extracellular vesicles, inducing Th1/Th17 polarization and promoting psoriasis development.
[Journal of investigative Dermatology]
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Finasteride was loaded in phospholipid vesicles and baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluated in vitro and in vivo.
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Using the kINPen argon plasma jet, a selective growth-reducing action of plasma treatment was identified in two squamous cell carcinoma cell lines in 2D and 3D cultures.
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Algae was extracted using Celluclast, and fucoidan fractions were recovered by step gradient ethanol precipitation. Refined fucoidan fractions were treated to human HaCaT keratinocytes and exposed to ultraviolet B.
[International Journal of Biological Macromolecules]
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Scientists investigated whether the therapeutic potential of an acellular porous scaffold made of type I collagen could be improved by the addition of a powerful trophic agent in the form of mesenchymal stromal cells conditioned medium in order to be used as an acellular scaffold for skin wound healing treatment.
[Journal of Cellular and Molecular Medicine]
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Scientists demonstrated a novel and highly accurate approach for the rapid identification of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) directly from infected wounds in 3D in vitro skin models.
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Investigators demonstrated that IL-22 might play an anti-apoptosis role on keratinocytes to balance cell proliferation and apoptosis in psoriatic epidermis.
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The authors used biomaterial-based approaches and bioengineered techniques to develop a 3D skin model with layers of endothelial cell networks, dermal fibroblasts, and multilayered keratinocytes.
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Merakris Therapeutics, LLC. announced that the Centers for Medicare & Medicaid Services has assigned a Healthcare Common Procedure Coding System product code Q4248 for its topical skin graft substitute, Dermacyte Matrix.
[Merakris Therapeutics, LLC.]