Tag Archives: keratinocytes

Origin of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons

During 3D organoid formation, the origin of iPS cells affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences]
IJMS | Free Full-Text | Origin of the Induced Pluripotent Stem Cells Affects Their Differentiation into Dopaminergic Neurons | HTML. (n.d.). Retrieved August 13, 2020, from https://www.mdpi.com/1422-0067/21/16/5705/htm Cite
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Inhibition of Wnt Signaling Pathway Suppresses Radiation-Induced Dermal Fibrosis

Radiation with a single dose of 2 Gy not only facilitated fibrosis in cultured human dermal fibroblasts via activation of the Wnt/β-catenin pathway but also initiated EMT in cultured keratinocytes, developing collagen-producing mesenchymal cells.
[Scientific Reports]
Lee, D. W., Lee, W. J., Cho, J., Yun, C.-O., Roh, H., Chang, H. P., Roh, T. S., Lee, J. H., & Lew, D. H. (2020). Inhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis. Scientific Reports, 10(1), 13594. https://doi.org/10.1038/s41598-020-70243-3 Cite
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Autologous Transplantation of Adipose-Derived Stromal Cells Combined with Sevoflurane Ameliorates Acute Lung Injury Induced by Cecal Ligation and Puncture in Rats

Researchers determined if the combination of sevoflurane and adipose-derived stromal cells exerted additional protective effects against acute lung injury induced by cecal ligation and puncture in rats.
[Scientific Reports]
Liang, Z., Zhou, H., Tang, R., Zhang, S., Chen, X., & Pei, L. (2020). Autologous transplantation of adipose-derived stromal cells combined with sevoflurane ameliorates acute lung injury induced by cecal ligation and puncture in rats. Scientific Reports, 10(1), 13760. https://doi.org/10.1038/s41598-020-70767-8 Cite
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Small Extracellular Vesicles Containing miR-381-3p from Keratinocytes Promotes Th1/Th17 Polarization in Psoriasis

Investigators proposed that psoriatic keratinocytes transferred miR-381-3p to CD4 + T cells via small extracellular vesicles, inducing Th1/Th17 polarization and promoting psoriasis development.
[Journal of investigative Dermatology]
Abstract

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Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders

Finasteride was loaded in phospholipid vesicles and baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluated in vitro and in vivo.
[Nanoscale]
AbstractGraphical Abstract

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Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo

Using the kINPen argon plasma jet, a selective growth-reducing action of plasma treatment was identified in two squamous cell carcinoma cell lines in 2D and 3D cultures.
[Cancers]
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Fucoidan Refined by Sargassum confusum Indicate Protective Effects Suppressing Photo-Oxidative Stress and Skin Barrier Perturbation in UVB-Induced Human Keratinocytes

Algae was extracted using Celluclast, and fucoidan fractions were recovered by step gradient ethanol precipitation. Refined fucoidan fractions were treated to human HaCaT keratinocytes and exposed to ultraviolet B.
[International Journal of Biological Macromolecules]
Abstract

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Mesenchymal Stromal Cell‐Derived Factors Promote the Colonization of Collagen 3D Scaffolds with Human Skin Cells

Scientists investigated whether the therapeutic potential of an acellular porous scaffold made of type I collagen could be improved by the addition of a powerful trophic agent in the form of mesenchymal stromal cells conditioned medium in order to be used as an acellular scaffold for skin wound healing treatment.
[Journal of Cellular and Molecular Medicine]
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Direct Identification of Bacterial and Human Proteins from Infected Wounds in Living 3D Skin Models

Scientists demonstrated a novel and highly accurate approach for the rapid identification of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) directly from infected wounds in 3D in vitro skin models.
[Scientific Reports]
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Elevated IL-22 in Psoriasis Plays an Anti-apoptotic Role in Keratinocytes through Mediating Bcl-xL/Bax

Investigators demonstrated that IL-22 might play an anti-apoptosis role on keratinocytes to balance cell proliferation and apoptosis in psoriatic epidermis.
[Apoptosis]
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Biofabrication of Endothelial Cell, Dermal Fibroblast, and Multilayered Keratinocyte Layers for Skin Tissue Engineering

The authors used biomaterial-based approaches and bioengineered techniques to develop a 3D skin model with layers of endothelial cell networks, dermal fibroblasts, and multilayered keratinocytes.
[Biofabrication]
Abstract

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Merakris Therapeutics, LLC Announces the Commercial Launch of Dermacyte® Matrix and CMS Assignment of an HCPCS Code for Use as a Skin Graft Substitute

Merakris Therapeutics, LLC. announced that the Centers for Medicare & Medicaid Services has assigned a Healthcare Common Procedure Coding System product code Q4248 for its topical skin graft substitute, Dermacyte Matrix.
[Merakris Therapeutics, LLC.]
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