The authors demonstrated that Pannexin 3 (Panx3) regulated skin development by modulating the transcription factor, Epiprofin (Epfn). In cell culture, Panx3 overexpression promoted HaCaT cell differentiation, cell cycle exit and enhanced Epfn expression.
Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
6807162 U9X4ZYET items 1 apa default asc 1
Scientists investigated whether human interfollicular epidermal keratinocytes with stem-like features, characterized by a α6bri/CD71dim expression, could replace human hair follicular keratinocytes for the recreation of the hair follicle epithelium and respective epithelial-mesenchymal interactions.
[Stem Cell Research & Therapy]
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The authors demonstrated there to be dispersal of phosphorylated Lamin A/C to structures throughout the cytoplasm in differentiating keratinocytes.
[Cell Death & Differentiation]
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Rogerson, C., Wotherspoon, D. J., Tommasi, C., Button, R. W., & O’Shaughnessy, R. F. L. (2021). Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation. Cell Death & Differentiation, 1–16. https://doi.org/10.1038/s41418-020-00712-9 Cite
The authors investigated the efficacy of Omega-7 isolated from the sea buckthorn oil in ovine burn wound healing models. In vitro, proliferation and migration assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively.
6807162 PMHLXE7M items 1 apa default asc 1
Niimi, Y., Pérez-Bello, D., Ihara, K., Fukuda, S., Jacob, S., Andersen, C. R., Baljinnyam, T., Kim, J., Alharbi, S., Prough, D. S., & Enkhbaatar, P. (2021). Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds. Scientific Reports, 11(1), 975. https://doi.org/10.1038/s41598-020-79597-0 Cite
Scientists examined the anti-inflammatory effects of carbon dioxide (CO2) in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed.
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Sayama, K., Yuki, K., Sugata, K., Fukagawa, S., Yamamoto, T., Ikeda, S., & Murase, T. (2021). Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Scientific Reports, 11(1), 379. https://doi.org/10.1038/s41598-020-79519-0 Cite
The authors describe a method of delivery of chondroitin sulfate to skin as nanoparticles and demonstrated its anti-inflammatory and antioxidant role using UV irradiation as a model condition.
[ACS Applied Materials & interfaces]
6807162 PRFWR3EA items 1 apa default asc 1
The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology]
The effects of Epidermal Growth Factor Receptor inhibitors (EGFRi) and Vascular Endothelial Growth Factor Receptor inhibitors at therapeutically relevant concentrations were assessed on proliferation and differentiation markers of human keratinocytes in a novel 3D micro-epidermis tissue culture model.
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The phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract.
6807162 55PGS76F items 1 apa default asc 1
di Giacomo, V., Recinella, L., Chiavaroli, A., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Politi, M., Antolini, M. D., Acquaviva, A., Bacchin, F., Di Mascio, M., Leone, S., Brunetti, L., Menghini, L., Carradori, S., Zengin, G., Ak, G., & Ferrante, C. (2021). Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens. Antioxidants, 10(1), 44. https://doi.org/10.3390/antiox10010044 Cite
The authors investigated the effects of electromagnetic fields with long-term evolution and 5G bandwidth on skin pigmentation in vitro.
[International Journal of Molecular Sciences]
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