Pannexin 3 Regulates Skin Development via Epiprofin

The authors demonstrated that Pannexin 3 (Panx3) regulated skin development by modulating the transcription factor, Epiprofin (Epfn). In cell culture, Panx3 overexpression promoted HaCaT cell differentiation, cell cycle exit and enhanced Epfn expression.
[Scientific Reports]
Zhang, P., Ishikawa, M., Doyle, A., Nakamura, T., He, B., & Yamada, Y. (2021). Pannexin 3 regulates skin development via Epiprofin. Scientific Reports, 11(1), 1779. https://doi.org/10.1038/s41598-021-81074-1 Cite
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Epidermal Progenitors Suppress GRHL3-Mediated Differentiation through Intronic Polyadenylation Promoted by CPSF-HNRNPA3 Collaboration

Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications]
Chen, X., Lloyd, S. M., Kweon, J., Gamalong, G. M., & Bao, X. (2021). Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications, 12(1), 448. https://doi.org/10.1038/s41467-020-20674-3 Cite
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Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

Scientists investigated whether human interfollicular epidermal keratinocytes with stem-like features, characterized by a α6bri/CD71dim expression, could replace human hair follicular keratinocytes for the recreation of the hair follicle epithelium and respective epithelial-mesenchymal interactions.
[Stem Cell Research & Therapy]
Abreu, C. M., Pirraco, R. P., Reis, R. L., Cerqueira, M. T., & Marques, A. P. (2021). Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment. Stem Cell Research & Therapy, 12(1), 62. https://doi.org/10.1186/s13287-020-02104-9 Cite
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Akt1-Associated Actomyosin Remodeling Is Required for Nuclear Lamina Dispersal and Nuclear Shrinkage in Epidermal Terminal Differentiation

The authors demonstrated there to be dispersal of phosphorylated Lamin A/C to structures throughout the cytoplasm in differentiating keratinocytes.
[Cell Death & Differentiation]
Rogerson, C., Wotherspoon, D. J., Tommasi, C., Button, R. W., & O’Shaughnessy, R. F. L. (2021). Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation. Cell Death & Differentiation, 1–16. https://doi.org/10.1038/s41418-020-00712-9 Cite
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Omega-7 Oil Increases Telomerase Activity and Accelerates Healing of Grafted Burn and Donor Site Wounds

The authors investigated the efficacy of Omega-7 isolated from the sea buckthorn oil in ovine burn wound healing models. In vitro, proliferation and migration assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively.
[Scientific Reports]
Niimi, Y., Pérez-Bello, D., Ihara, K., Fukuda, S., Jacob, S., Andersen, C. R., Baljinnyam, T., Kim, J., Alharbi, S., Prough, D. S., & Enkhbaatar, P. (2021). Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds. Scientific Reports, 11(1), 975. https://doi.org/10.1038/s41598-020-79597-0 Cite
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Carbon Dioxide Inhibits UVB-Induced Inflammatory Response by Activating the Proton-Sensing Receptor, GPR65, in Human Keratinocytes

Scientists examined the anti-inflammatory effects of carbon dioxide (CO2) in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed.
[Scientific Reports]
Sayama, K., Yuki, K., Sugata, K., Fukagawa, S., Yamamoto, T., Ikeda, S., & Murase, T. (2021). Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Scientific Reports, 11(1), 379. https://doi.org/10.1038/s41598-020-79519-0 Cite
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Topical Application of Peptide-Chondroitin Sulfate Nanoparticles Allows Efficient Photoprotection in Skin

The authors describe a method of delivery of chondroitin sulfate to skin as nanoparticles and demonstrated its anti-inflammatory and antioxidant role using UV irradiation as a model condition.
[ACS Applied Materials & interfaces]
Mishra, S., G, B. R., Pal, S., Bano, S., Gupta, A., Kumari, A., & Ganguli, M. (2021). Topical Application of Peptide–Chondroitin Sulfate Nanoparticles Allows Efficient Photoprotection in Skin. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.0c22011 Cite
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Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology]
Palmer, M. A., Smart, E., & Haslam, I. S. (2021). Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-020-01957-8 Cite
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EGFR Inhibitors Switch Keratinocytes From a Proliferative to a Differentiative Phenotype Affecting Epidermal Development and Barrier Function

The effects of Epidermal Growth Factor Receptor inhibitors (EGFRi) and Vascular Endothelial Growth Factor Receptor inhibitors at therapeutically relevant concentrations were assessed on proliferation and differentiation markers of human keratinocytes in a novel 3D micro-epidermis tissue culture model.
[BMC Cancer]
Joly-Tonetti, N., Ondet, T., Monshouwer, M., & Stamatas, G. N. (2021). EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function. BMC Cancer, 21(1), 5. https://doi.org/10.1186/s12885-020-07685-5 Cite
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Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens

The phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract.
[Antioxidants]
di Giacomo, V., Recinella, L., Chiavaroli, A., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Politi, M., Antolini, M. D., Acquaviva, A., Bacchin, F., Di Mascio, M., Leone, S., Brunetti, L., Menghini, L., Carradori, S., Zengin, G., Ak, G., & Ferrante, C. (2021). Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens. Antioxidants, 10(1), 44. https://doi.org/10.3390/antiox10010044 Cite
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Effects of Electromagnetic Waves with LTE and 5G Bandwidth on the Skin Pigmentation In Vitro

The authors investigated the effects of electromagnetic fields with long-term evolution and 5G bandwidth on skin pigmentation in vitro.
[International Journal of Molecular Sciences]
Kim, K., Lee, Y. S., Kim, N., Choi, H.-D., Kang, D.-J., Kim, H. R., & Lim, K.-M. (2021). Effects of Electromagnetic Waves with LTE and 5G Bandwidth on the Skin Pigmentation In Vitro. International Journal of Molecular Sciences, 22(1), 170. https://doi.org/10.3390/ijms22010170 Cite
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