Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
[Journal of Materials Chemistry B]
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Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.
[Stem Cell Reviews and Reports]
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Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
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Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
Investigators examined whether mineralocorticoid receptor antagonists can ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.
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Lee, H., Choi, E.-J., Kim, E. J., Son, E. D., Kim, H.-J., Park, W.-S., Kang, Y.-G., Shin, K.-O., Park, K., Kim, J.-C., Kim, S.-N., & Choi, E. H. (2021). A novel mineralocorticoid receptor antagonist, 7,3’,4’-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids. Scientific Reports, 11(1), 11920. https://doi.org/10.1038/s41598-021-91450-6 Cite
Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.
Researchers used both pharmacologic and genetic approaches in cells and mice to show that both the platelet-activating factor receptor and enzyme acid sphingomyelinase were necessary for UVB-MVP generation.
[Journal of Clinical Investigation]
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Liu, L., Awoyemi, A. A., Fahy, K. E., Thapa, P., Borchers, C., Wu, B. Y., McGlone, C. L., Schmeusser, B., Sattouf, Z., Rohan, C. A., Williams, A. R., Cates, E. E., Knisely, C., Kelly, L. E., Bihl, J. C., Cool, D. R., Sahu, R. P., Wang, J., Chen, Y., … Travers, J. B. (2021). Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation–induced systemic immunosuppression. The Journal of Clinical Investigation, 131(10). https://doi.org/10.1172/JCI144963 Cite
Investigators tested the effects of Methylene blue on UVB ray-induced DNA double-strand breaks in primary human keratinocytes.
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The authors demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids implicated the involvement of the mouse homologue of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells.
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Scientists found increased average methylation in mouse cutaneous squamous cell carcinomas (cSCC) as well as in stem-cell like, but not keratinocyte-like, human cSCC.
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Researchers found that the expression of NEDD4-binding protein 1 (N4BP1) in skin was highest among all 54 tested tissues, and its expression was further upregulated in psoriatic skin.
[Cell Death & Disease]
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Gou, C., Ni, W., Ma, P., Zhao, F., Wang, Z., Sun, R., Wu, Y., Wu, Y., Chen, M., Chen, H., Zhang, J., Shen, Y., Xiao, M., Lu, C., Mao, R., & Fan, Y. (2021). The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Cell Death & Disease, 12(5), 1–16. https://doi.org/10.1038/s41419-021-03774-w Cite