Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

The authors evaluated the use and trends of active comparator trial designs in dermatology.
[Scientific Reports]
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Female Immunity Protects from Cutaneous Squamous Cell Carcinoma

Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids

Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters]
Sachdeva, U. M., Shimonosono, M., Flashner, S., Cruz-Acuña, R., Gabre, J. T., & Nakagawa, H. (2021). Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.031 Cite
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Bacteria Induce Skin Regeneration via IL-1β Signaling

The Scientists assessed the function of skin bacteria in wound healing and wound-induced hair follicle neogenesis (WIHN), a rare adult organogenesis model.
[Cell Host & Microbe]
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Human Skin Aging is Associated with Increased Expression of the Histone Variant H2A.J in the Epidermis

The Scientists investigated histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging.
[npj Aging and Mechanisms of Disease]
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In Vitro Skin Culture Media Influence the Viability and Inflammatory Response of Primary Macrophages

Scientists showed that skin maturation was affected by culture in macrophage medium, while macrophages showed reduced viability, altered cell morphology and decreased response to pro- and anti-inflammatory stimuli in skin differentiation media, both in 2D and 3D.
[Scientific Reports]
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Interaction of the NRF2 and p63 Transcription Factors Promotes Keratinocyte Proliferation in the Epidermis

The authors discovered an unexpected interaction between the cytoprotective transcription factor NRF2 and p63- a key player in epithelial morphogenesis.
[Nucleic Acids Research]
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MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
[Dermatology]
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A Role for Keratin 17 during DNA Damage Response and Tumor Initiation

K17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.
[Proceedings of the National Academy of Sciences of the United States of America]
Nair, R. R., Hsu, J., Jacob, J. T., Pineda, C. M., Hobbs, R. P., & Coulombe, P. A. (2021). A role for keratin 17 during DNA damage response and tumor initiation. Proceedings of the National Academy of Sciences, 118(13). https://doi.org/10.1073/pnas.2020150118 Cite
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A Role for Dynlt3 in Melanosome Movement, Distribution, Acidity and Transfer

The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
[Communications Biology]
Aktary, Z., Conde-Perez, A., Rambow, F., Di Marco, M., Amblard, F., Hurbain, I., Raposo, G., Delevoye, C., Coscoy, S., & Larue, L. (2021). A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01917-5 Cite
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Effects of Metal Nanoparticles on Tight Junction-Associated Proteins via HIF-1α/miR-29b/MMPs Pathway in Human Epidermal Keratinocytes

Scientists demonstrated that exposure of human epidermal keratinocytes to Nano-Ni caused increased HIF-1α nuclear accumulation and increased transcription and activity of MMP-2 and MMP-9 and down-regulation of miR-29b and tight junction-associated proteins.
[Particle and Fibre Toxicology]
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