The authors evaluated the use and trends of active comparator trial designs in dermatology.
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Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
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The Scientists assessed the function of skin bacteria in wound healing and wound-induced hair follicle neogenesis (WIHN), a rare adult organogenesis model.
[Cell Host & Microbe]
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The Scientists investigated histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging.
[npj Aging and Mechanisms of Disease]
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Scientists showed that skin maturation was affected by culture in macrophage medium, while macrophages showed reduced viability, altered cell morphology and decreased response to pro- and anti-inflammatory stimuli in skin differentiation media, both in 2D and 3D.
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The authors discovered an unexpected interaction between the cytoprotective transcription factor NRF2 and p63- a key player in epithelial morphogenesis.
[Nucleic Acids Research]
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Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
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K17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.
[Proceedings of the National Academy of Sciences of the United States of America]
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The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
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Aktary, Z., Conde-Perez, A., Rambow, F., Di Marco, M., Amblard, F., Hurbain, I., Raposo, G., Delevoye, C., Coscoy, S., & Larue, L. (2021). A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01917-5 Cite
Scientists demonstrated that exposure of human epidermal keratinocytes to Nano-Ni caused increased HIF-1α nuclear accumulation and increased transcription and activity of MMP-2 and MMP-9 and down-regulation of miR-29b and tight junction-associated proteins.
[Particle and Fibre Toxicology]
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