Skin Protein-Derived Peptide-Conjugated Vesicular Nanocargos for Selected Skin Cell Targeting and Consequent Activation

Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
[Journal of Materials Chemistry B]
Cho, J. H., Kang, J. Y., Kim, S., Baek, H. R., Kim, J., Jang, K.-S., & Kim, J. W. (2021). Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00935D Cite
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An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells

Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.
[Stem Cell Reviews and Reports]
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Single-Cell RNA Sequencing of Human Nail Unit Defines RSPO4 Onychofibroblasts and SPINK6 Nail Epithelium

Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
[Communications Biology]
Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
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A Novel Mineralocorticoid Receptor Antagonist, 7,3′, 4′-Trihydroxyisoflavone Improves Skin Barrier Function Impaired by Endogenous or Exogenous Glucocorticoids

Investigators examined whether mineralocorticoid receptor antagonists can ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.
[Scientific Reports]
Lee, H., Choi, E.-J., Kim, E. J., Son, E. D., Kim, H.-J., Park, W.-S., Kang, Y.-G., Shin, K.-O., Park, K., Kim, J.-C., Kim, S.-N., & Choi, E. H. (2021). A novel mineralocorticoid receptor antagonist, 7,3’,4’-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids. Scientific Reports, 11(1), 11920. https://doi.org/10.1038/s41598-021-91450-6 Cite
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3D Cell Culture Using a Clinostat Reproduces Microgravity-Induced Skin Changes

Investigators showed that under time-averaged simulated microgravity, the thickness of the endothelial cell arrangement increased by up to 59.75%, indicating skin irritation due to vasodilation, and that the diameter of keratinocytes and fibroblast co-cultured spheroids decreased by 6.66%, representing skin thinning.
[npj Microgravity]
Choi, D. H., Jeon, B., Lim, M. H., Lee, D. H., Ye, S.-K., Jeong, S.-Y., & Kim, S. (2021). 3D cell culture using a clinostat reproduces microgravity-induced skin changes. Npj Microgravity, 7(1), 1–7. https://doi.org/10.1038/s41526-021-00148-6 Cite
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High Proliferation and Delamination during Skin Epidermal Stratification

Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.
[Nature Communications]
Damen, M., Wirtz, L., Soroka, E., Khatif, H., Kukat, C., Simons, B. D., & Bazzi, H. (2021). High proliferation and delamination during skin epidermal stratification. Nature Communications, 12(1), 3227. https://doi.org/10.1038/s41467-021-23386-4 Cite
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Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation–Induced Systemic Immunosuppression

Researchers used both pharmacologic and genetic approaches in cells and mice to show that both the platelet-activating factor receptor and enzyme acid sphingomyelinase were necessary for UVB-MVP generation.
[Journal of Clinical Investigation]
Liu, L., Awoyemi, A. A., Fahy, K. E., Thapa, P., Borchers, C., Wu, B. Y., McGlone, C. L., Schmeusser, B., Sattouf, Z., Rohan, C. A., Williams, A. R., Cates, E. E., Knisely, C., Kelly, L. E., Bihl, J. C., Cool, D. R., Sahu, R. P., Wang, J., Chen, Y., … Travers, J. B. (2021). Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation–induced systemic immunosuppression. The Journal of Clinical Investigation, 131(10). https://doi.org/10.1172/JCI144963 Cite
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Ultraviolet Radiation Protection Potentials of Methylene Blue for Human Skin and Coral Reef Health

Investigators tested the effects of Methylene blue on UVB ray-induced DNA double-strand breaks in primary human keratinocytes.
[Scientific Reports]
Xiong, Z.-M., Mao, X., Trappio, M., Arya, C., Kordi, J. el, & Cao, K. (2021). Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health. Scientific Reports, 11(1), 10871. https://doi.org/10.1038/s41598-021-89970-2 Cite
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Differentiation-Related Zinc Finger Protein 750 Suppresses Cell Growth in Esophageal Squamous Cell Carcinoma

The authors demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids implicated the involvement of the mouse homologue of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells.
[Oncology Letters]
Ana Choi, S. S., Ko, J. M.-Y., Yu, V. Z., Ning, L., & Lung, M. L. (2021). Differentiation‑related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma. Oncology Letters, 22(1), 1–10. https://doi.org/10.3892/ol.2021.12774 Cite
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Clinically Relevant Aberrant Filip1l DNA Methylation Detected in a Murine Model of Cutaneous Squamous Cell Carcinoma

Scientists found increased average methylation in mouse cutaneous squamous cell carcinomas (cSCC) as well as in stem-cell like, but not keratinocyte-like, human cSCC.
[Ebiomedicine]
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The Endoribonuclease N4BP1 Prevents Psoriasis by Controlling Both Keratinocytes Proliferation and Neutrophil Infiltration

Researchers found that the expression of NEDD4-binding protein 1 (N4BP1) in skin was highest among all 54 tested tissues, and its expression was further upregulated in psoriatic skin.
[Cell Death & Disease]
Gou, C., Ni, W., Ma, P., Zhao, F., Wang, Z., Sun, R., Wu, Y., Wu, Y., Chen, M., Chen, H., Zhang, J., Shen, Y., Xiao, M., Lu, C., Mao, R., & Fan, Y. (2021). The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Cell Death & Disease, 12(5), 1–16. https://doi.org/10.1038/s41419-021-03774-w Cite
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