In vitro, Oncostatin M promoted invasiveness of keratinocytes and cutaneous squamous cell carcinoma cells and suppressed apoptosis of irradiated keratinocytes.
6807162 X8776UAE items 1 apa default asc 1
Nguyen, T. N., Rajapakshe, K., Nicholas, C., Tordesillas, L., Ehli, E. A., Davis, C. M., Coarfa, C., Flores, E. R., Dickinson, S. E., Curiel-Lewandrowski, C., & Tsai, K. Y. (2020). Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development. Scientific Reports, 10(1), 17209. https://doi.org/10.1038/s41598-020-74051-7 Cite
Researchers investigated the viability and proliferation of osteoblasts, fibroblasts and oral keratinocytes under stratified medium modification and assessed the differentiation of osteoclasts in each co-culture.
6807162 PCUPYBSL items 1 apa default asc 1
Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes | Scientific Reports. (n.d.). Retrieved October 8, 2020, from https://www.nature.com/articles/s41598-020-73941-0 Cite
The authors found that EZH2 and H3K27me3 were both overexpressed in the epidermis of psoriatic lesional skin compared to normal skin. In vitro, the expression of EZH2 and H3K27me3 was stimulated in human keratinocytes treated with mixture of psoriasis-related cytokines pool.
[Cell Death & Disease]
6807162 3PZ4EQMR items 1 apa default asc 1
EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation | Cell Death & Disease. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41419-020-03028-1 Cite
In vitro human keratinocyte cell culture, ex vivo human skin organ explants and the eczema prone Nc/Tnd mouse were used as model systems to assess type-2 promoting immune responses to S. aureus.
[Journal of Allergy and Clinical Immunology]
6807162 NHN5EQMN items 1 apa default asc 1
Kindi, A. A., Williams, H., Matsuda, K., Alkahtani, A. M., Saville, C., Bennett, H., Alshammari, Y., Tan, S. Y., O’Neill, C., Tanaka, A., Matsuda, H., Arkwright, P. D., & Pennock, J. L. (2020). Staphylococcus aureus Second Immunoglobulin-Binding Protein drives atopic dermatitis via IL-33. Journal of Allergy and Clinical Immunology, 0(0). https://doi.org/10.1016/j.jaci.2020.09.023 Cite
Researchers demonstrated that among 18 markers of terminally differentiated keratinocytes of stratum granulosum and stratum corneum in vivo, only four (CDSN, KPRP, LCE1C, and SPRR4) have reproduced their expression pattern in vitro.
6807162 ATZCQRDU items 1 apa default asc 1
Filamentous and picoplanktonic cyanobacteria extracts were analyzed for their pigment profile, phenolic content, antioxidant potential, cytotoxicity against keratinocytes, fibroblasts, endothelial cells and capacity to inhibit hyaluronidase.
6807162 WPQY6JX5 items 1 apa default asc 1
Morone, J., Lopes, G., Preto, M., Vasconcelos, V., & Martins, R. (2020). Exploitation of Filamentous and Picoplanktonic Cyanobacteria for Cosmetic Applications: Potential to Improve Skin Structure and Preserve Dermal Matrix Components. Marine Drugs, 18(9), 486. https://doi.org/10.3390/md18090486 Cite
Investigators uncovered COL17 as a binding partner of the aPKC‐PAR complex, which is a key regulating factor of cell polarity. Immunoprecipitation‐immunoblot assay and protein‐protein binding assay revealed that COL17 interacts with aPKC and PAR3. Type XVII collagen (COL17) deficiency or epidermis‐specific aPKCλ deletion destabilized PAR3 distribution in the epidermis, while aPKCζ knockout did not.
6606345 QA8MTJ59 items 1 apa default asc 1
Scientists describe optimization of current methods and present new protocols for using human papillomavirus capsids to deliver non-viral DNA, thereby providing an alternative to DNA transfection. Using keratinocyte generated extracellular matrices could enhance infection efficiency in keratinocytes, hepatocytes and neuronal cells.
Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.
[Stem Cell Research & Therapy]
6807162 GBZ282EH items 1 apa default asc 1
Zhang, Q., Wen, J., Liu, C., Ma, C., Bai, F., Leng, X., Chen, Z., Xie, Z., Mi, J., & Wu, X. (2020). Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo. Stem Cell Research & Therapy, 11(1), 407. https://doi.org/10.1186/s13287-020-01924-z Cite
Using cytokine array screening, scientists found that autophagy deficiency inhibited the transcription and production of the cytokine CCL2/MCP-1 by TNF.
The authors investigate the association of exosomes with vitiligo and emphasize the role of exosomes in immune regulation, melanocyte–keratinocyte interactions, and melanogenesis.