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keratinocytes

EGFR-Mediated Epidermal Stem Cell Motility Drives Skin Regeneration through COL17A1 Proteolysis

[Journal of Cell Biology] Researchers conducted culture experiments that proved epidermal growth factor receptor (EGFR) activation drove human keratinocyte stem cell motility.

Effect of 1-MHz Ultrasound on the Proinflammatory Interleukin-6 Secretion in Human Keratinocytes

[Scientific Reports] Researchers investigated whether mechanical energy transported by low intensity ultrasound could generate a mechanical stress able to induce the release of inflammatory cytokine such as interleukin-6 in the human keratinocyte cell line, HaCaT.

GPCR-Mediated EGFR Transactivation Ameliorates Skin Toxicities Induced by Afatinib

[Acta Pharmacologica Sinica] Researchers examined the ability of three different G-protein-coupled receptor (GPCR) agonists to reverse signaling inhibition and ameliorate rash induced by epidermal growth factor receptor inhibitors (EGFRi).

The Current Challenges on Spray-Based Cell Delivery to the Skin Wounds

[Tissue Engineering Part C-Methods] Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.

RAS Induced Senescence of Skin Keratinocytes Is Mediated through Rho-Associated Protein Kinase (ROCK)

[Molecular Carcinogenesis] Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.

Cytosolic-DNA-Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

[Journal of Investigative Dermatology] Stimulator of IFN genes (STING) is a universal receptor that recognizes cytosolic DNA and triggers innate immune activation. Investigators elucidated the role of STING in the inflammation during psoriasis.

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