keratinocytes

[Scientific Reports] Scientists aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism.

[Immunity] Scientists demonstrated that inhibition of protein synthesis during viral infection is sensed as a virulence strategy and initiates pyroptosis in human keratinocytes.

[Scientific Reports] Scientists observed in vitro antiproliferative activity in six tumor cell lines for free protein after 48 hours of treatment with free and nanoencapsulated commercial bromelain.

[Nature Communications] Scientists reported that single-cell transcriptome analysis of primary human epidermal cultures identifies categories of genes clearly distinguishing the different keratinocyte clonal types, which are hierarchically organized along a continuous, mainly linear trajectory showing that stem cells sequentially generate progenitors producing terminally differentiated cells.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that upper stratum granulosum cell death was preceded by prolonged (∼60 min) Ca2+ elevation and rapid induction of intracellular acidification.

[Archives of Toxicology] To investigate the potential dermotoxicity of Deoxynivalenol (DON), epidermoid squamous cell carcinoma cells A431 were compared to primary human neonatal keratinocytes (HEKn) cells via proteome/phosphoproteome profiling.