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keratinocytes

UV-induced DNA Damage in Skin is Reduced by CaSR Inhibition

[Photochemistry and Photobiology] Researchers investigated whether the calcium-sensing receptor (CaSR) was involved more directly in protection from UV damage in studies of human keratinocytes in primary culture and in mouse skin studied in vivo.

CircEIF5 Contributes to Hyperproliferation and Inflammation of Keratinocytes in Psoriasis via P-NFκB and P-STAT3 Signaling Pathway

[Experimental Dermatology] Researchers identified that circular RNA EIF5 (circEIF5) was highly expressed in psoriasis tissues compared to the normal skin.

PP2Acα Regulates Epidermal Cell Proliferation via the EGFR/AKT/mTOR Pathway in Psoriasis-Like Skin Lesions Caused by PPP2CA Deficiency

[Experimental Dermatology] The authors showed that protein phosphatase 2 A catalytic subunit α isoform (PP2Acα) negatively regulated epidermal growth factor receptor (EGFR) phosphorylation and epidermal cell proliferation, and EGFR inhibitors potentially alleviated PP2Acα by inhibiting epidermal cell proliferation.

CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway

[Inflammation] Investigators found that circular RNA OAS3 (circOAS3) expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.

Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing

[Molecular Pharmaceutics] MiR-155-inhibitor-loaded MSC-derived exosomes showed synergistic effects in keratinocyte migration, restoration of FGF-7 levels, and anti-inflammatory action, leading to accelerated wound healing mediated by negative regulation of miR-155, using an in vitro co-culture model and in vivo mouse model of the diabetic wound.

Abnormal Expression of Interleukin-6 Is Associated with Epidermal Alternations in Localized Scleroderma

[Clinical Rheumatology] Scientists investigated the structural and functional changes in the localized scleroderma (LSc) epidermis and further explored the underlying mechanisms, providing a new angle to treat LSc in the clinic.

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