Identification of Candidate PAX2-Regulated Genes Implicated in Human Kidney Development

Scientists hypothesized that key human PAX2-dependent kidney development genes are differentially expressed in nephron progenitor cells from induced pluripotent stem cells in patients with renal coloboma syndrome relative to healthy individuals.
[Scientific Reports]
Yamamura, Y., Furuichi, K., Murakawa, Y., Hirabayashi, S., Yoshihara, M., Sako, K., Kitajima, S., Toyama, T., Iwata, Y., Sakai, N., Hosomichi, K., Murphy, P. M., Tajima, A., Okita, K., Osafune, K., Kaneko, S., & Wada, T. (2021). Identification of candidate PAX2-regulated genes implicated in human kidney development. Scientific Reports, 11(1), 9123. https://doi.org/10.1038/s41598-021-88743-1 Cite
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Lithocholic Bile Acid Induces Apoptosis in Human Nephroblastoma Cells: A Non-Selective Treatment Option

Scientists evaluated the effects of Lithocholic bile acid (LCA) on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used.
[Scientific Reports]
Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option | Scientific Reports. (n.d.). Retrieved November 23, 2020, from https://www.nature.com/articles/s41598-020-77436-w Cite
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Artificial Cells Drive Neural Differentiation

Scientists suggested that artificial cells were a versatile chassis for the in situ synthesis and on-demand release of chemical signals that elicited desired phenotypic changes of eukaryotic cells, including neuronal differentiation.
[Science Advances]
Toparlak, Ö. D., Zasso, J., Bridi, S., Serra, M. D., Macchi, P., Conti, L., Baudet, M.-L., & Mansy, S. S. (2020). Artificial cells drive neural differentiation. Science Advances, 6(38), eabb4920. https://doi.org/10.1126/sciadv.abb4920 Cite
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T-Type Calcium Channel Antagonist, TTA-A2 Exhibits Anti-Cancer Properties in 3D Spheroids of A549, a Lung Adenocarcinoma Cell Line

Scientists studied TTA-A2 and paclitaxel in lung adenocarcinoma cell line- A549, cancer cells and human embryonic kidney cell line- HEK 293, control cell, in their monolayer and spheroids forms for viability, proliferation, morphology change, migration, and invasion-after 48–96 hours of treatment.
[Life Sciences]
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Formation and Optimization of Three-Dimensional Organoids Generated From Urine-Derived Stem Cells for Renal Function In Vitro

Researchers aimed to develop a novel kind of 3D organoids generated from urine-derived stem cells and to explore whether kidney-specific extracellular matrix could enable such organoids for renal function in vitro.
[Stem Cell Research & Therapy]
Sun, G., Ding, B., Wan, M., Chen, L., Jackson, J., & Atala, A. (2020). Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro. Stem Cell Research & Therapy, 11(1), 309. https://doi.org/10.1186/s13287-020-01822-4 Cite
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Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis

Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Vagus Nerve Stimulation Even after Injury Ameliorates Cisplatin-Induced Nephropathy via Reducing Macrophage Infiltration

To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports]
Uni, R., Inoue, T., Nakamura, Y., Fukaya, D., Hasegawa, S., Wu, C.-H., … Inagi, R. (2020). Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration. Scientific Reports, 10(1), 9472. https://doi.org/10.1038/s41598-020-66295-0 Cite
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