Uremic Toxins Impair Skeletal Muscle Regeneration by Inhibiting Myoblast Proliferation, Reducing Myogenic Differentiation, and Promoting Muscular Fibrosis

This study analyzes the role of uremic toxins in sarcopenia at different stages of chronic kidney disease (CKD), evaluating changes in the muscular regeneration process. Cultured C2C12 cells were incubated with a combination of indoxyl sulphate and p-cresol at high doses or low doses resembling late or early CKD stages, respectively.
[Scientific Reports]
Alcalde-Estévez, E., Sosa, P., Asenjo-Bueno, A., Plaza, P., Olmos, G., Naves-Díaz, M., Rodríguez-Puyol, D., López-Ongil, S., & Ruiz-Torres, M. P. (2021). Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis. Scientific Reports, 11(1), 512. https://doi.org/10.1038/s41598-020-79186-1 Cite
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Recessive NOS1AP Variants Impair Actin Remodeling and Cause Glomerulopathy in Humans and Mice

Investigators demonstrated that recessive NOS1AP variants impaired CDC42/DIAPH-dependent actin remodeling, causing aberrant organoid glomerulogenesis, and leading to a glomerulopathy in humans and mice.
[Science Advances]
Majmundar, A. J., Buerger, F., Forbes, T. A., Klämbt, V., Schneider, R., Deutsch, K., Kitzler, T. M., Howden, S. E., Scurr, M., Tan, K. S., Krzeminski, M., Widmeier, E., Braun, D. A., Lai, E., Ullah, I., Amar, A., Kolb, A., Eddy, K., Chen, C. H., … Hildebrandt, F. (2021). Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice. Science Advances, 7(1), eabe1386. https://doi.org/10.1126/sciadv.abe1386 Cite
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MicroRNAs Are Critical in Regulating Smooth Muscle Cell Mineralization and Apoptosis during Vascular Calcification

The authors discuss the roles of microRNAs in the pathophysiological mechanisms of vascular calcification in smooth muscle cells and describes several interventions against vascular calcification by regulating microRNAs.
[Journal of Cellular and Molecular Medicine]
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WNT–β-Catenin Signaling – A Versatile Player in Kidney Injury and Repair

WNT–β-catenin signaling is involved in chronic kidney disease-associated vascular calcification and mineral bone disease. The WNT–β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf family.
[Nature Reviews Nephrology]
Schunk, S. J., Floege, J., Fliser, D., & Speer, T. (2020). WNT–β-catenin signalling — a versatile player in kidney injury and repair. Nature Reviews Nephrology, 1–13. https://doi.org/10.1038/s41581-020-00343-w Cite
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FGF/FGFR Signaling in Health and Disease

The authors provide a comprehensive overview of the current understanding of fibroblast growth factor (FGF) signaling and its roles in organ development, injury repair, and the pathophysiology of a spectrum of diseases, which is a consequence of FGF signaling dysregulation.
[Signal Transduction and Targeted Therapy]
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., Chen, H., Sun, X., Feng, J. Q., Qi, H., & Chen, L. (2020). FGF/FGFR signaling in health and disease. Signal Transduction and Targeted Therapy, 5(1), 1–38. https://doi.org/10.1038/s41392-020-00222-7 Cite
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Adebiyi Awarded $4.5 Million from the NIH for Vascular, Kidney Dysfunction Research

Over the last 10 years, Dr. Adebiyi’s laboratory has focused on investigating cellular mechanisms that control vascular and kidney functions in health and disease of newborns and adults. Dr. Adebiyi recently received two new grants from the National Institutes of Health to support these research initiatives.
[University of Tennessee (EurekaAlert!)]
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Extracellular Vesicle–Encapsulated IL-10 as Novel Nanotherapeutics against Ischemic AKI

Treatment with IL-10+ extracellular vesicles significantly ameliorated renal tubular injury and inflammation caused by ischemia/reperfusion injury, and potently prevented the transition to chronic kidney disease.
[Science Advances]
Tang, T.-T., Wang, B., Wu, M., Li, Z.-L., Feng, Y., Cao, J.-Y., Yin, D., Liu, H., Tang, R.-N., Crowley, S. D., Lv, L.-L., & Liu, B.-C. (2020). Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Science Advances, 6(33), eaaz0748. https://doi.org/10.1126/sciadv.aaz0748 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids

CRISPR-Cas9 technology deleted PKD1 in human induced pluripotent stem cell and the cells induced to differentiate along pathways leading to formation of either nephron progenitor or uteric bud organoids.
[Journal of the American Society of Nephrology]
Kuraoka, S., Tanigawa, S., Taguchi, A., Hotta, A., Nakazato, H., Osafune, K., Kobayashi, A., & Nishinakamura, R. (2020). PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids. Journal of the American Society of Nephrology. https://doi.org/10.1681/ASN.2020030378 Cite
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International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis

Investigators present an international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis.
[American Journal of Respiratory and Critical Care Medicine]
Moiseev, S., Bossuyt, X., Arimura, Y., Blockmans, D., Csernok, E., Damoiseaux, J., … Cohen Tervaert, J. W. (2020). International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202005-1628SO Cite
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