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leukemia cells
Hematopoiesis News
Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia
[Cancer Immunology Immunotherapy] Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.
Hematopoiesis News
Bone Mesenchymal Stem Cell-Derived Exosomal microRNA-7-5p Inhibits Progression of Acute Myeloid Leukemia by Targeting OSBPL11
[Journal of Nanobiotechnology] Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.
Hematopoiesis News
Interleukin-7 Receptor α Mutational Activation Can Initiate Precursor B Cell Acute Lymphoblastic Leukemia
[Nature Communications] The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.
Hematopoiesis News
Acute Myeloid Leukemia Cell Membrane-Coated Nanoparticles for Cancer Vaccination Immunotherapy
[Leukemia] Researchers reported the development of an acute myeloid leukemia cell membrane-coated nanoparticle vaccine platform, in which immune-stimulatory adjuvant-loaded nanoparticles were coated with leukemic cell membrane material.
Hematopoiesis News
Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia
[Molecular Cancer Research] Researchers revealed the breadth of SWI/SNF dependency in leukemia and supported targeting SWI/SNF catalytic function as a potential therapeutic strategy in acute myeloid leukemia.
Cell Therapy News
CD33-Directed Immunotherapy with Third-Generation Chimeric Antigen Receptor T Cells and Gemtuzumab Ozogamicin in Intact and CD33-Edited Acute Myeloid Leukemia and Hematopoietic Stem and Progenitor...
[International Journal of Cancer] Investigators introduced a CD33-directed third-generation CAR T cell product for the treatment of patients with acute myeloid leukemia.