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leukemia stem cells

Super-Enhancer Landscape Reveals Leukemia Stem Cell Reliance on X-box Binding Protein 1 as a Therapeutic Vulnerability

[Science Translational Medicine] Disruption of the super-enhancer-associated gene transcription by THZ1, a covalent cyclin-dependent kinase 7 inhibitor, efficiently eradicated leukemia stem cells in retroviral BCR-ABL–driven chronic myelogenous leukemia mice while sparing normal hematopoietic stem cells.

Regulatory T Cells Promote the Stemness of Leukemia Stem Cells through IL10 Cytokine-Related Signaling Pathway

[Leukemia] The increased stemness of acute myeloid leukemia (AML) cells promoted by Tregs was verified in vitro and in vivo, and researchers found that blocking the interaction between Tregs and AML cells may be a new approach to target leukemia stem cells in AML treatment.

Nuclear NAD+ Homeostasis Governed by NMNAT1 Prevents Apoptosis of Acute Myeloid Leukemia Stem Cells

[Science Advances] Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.

TNF-α-Induced Alterations in Stromal Progenitors Enhance Leukemic Stem Cell Growth via CXCR2 Signaling

[Cell Reports] Using a murine chronic myeloid leukemia (CML) model, investigators examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced HSC supportive capacity.

A KDM4A-PAF1-Mediated Epigenomic Network Is Essential for Acute Myeloid Leukemia Cell Self-Renewal and Survival

[Cell Death & Disease] Researchers delineated and functionally validated the epigenomic network regulated by KDM4A, and showed that selective loss of KDM4A was sufficient to induce apoptosis in a broad spectrum of human acute myeloid leukemia cells.

Targeting CD123 in Hematologic Malignancies: Identifying Suitable Patients for Targeted Therapy

[Leukemia & Lymphoma] Scientists review the methodologies available for CD123 assessment and discuss the biological and clinical characteristics of patients for whom CD123-targeting therapies may have a clinical impact.

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