leukemia stem cells

[Oncogene] Investigators found that protein lysine methyltransferase G9A was overexpressed in chronic myelogenous leukemia leukemia stem cells.

[Clinical Cancer Research] Scientists tested the safety and efficacy of chimeric antigen receptor T cell therapy in refractory/relapsed acute myeloid leukemia .

[Cell Stem Cell] Scientists discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients.

[Science Translational Medicine] HSC-derived Mixed Lineage Leukemia- acute myeloid leukemia gene fusions was highly resistant to chemotherapy and expressed elevated amounts of the multispecific anion transporter ABCC3.

[Cell Reports] Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-leukemia stem cells from myeloproliferative neoplasm patients reveal APOBEC3C upregulation, an increased C-to-T mutational burden, and hematopoietic stem and progenitor cell proliferation during progression, which can be recapitulated by lentiviral APOBEC3C overexpression.

[Cell Reports] The authors identified CD93 as an important regulator of self-renewal and proliferation of murine and human leukemia stem cells, but not hematopoietic stem cells.