Stabilization of Fatty Acid Synthesis Enzyme Acetyl-CoA Carboxylase 1 Suppresses Acute Myeloid Leukemia Development

Stable ACC1 protein expression suppressed the growth-promoting activity and increased ROS levels with the consumption of NADPH in a primary bone marrow culture, and delayed the onset of acute myeloid leukemia with increases in mature myeloid cells in mouse models.
[Journal of Clinical Investigation]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Core Binding Factor Acute Myelogenous Leukemia-2021 Treatment Algorithm

The authors discussed the effective implementation of available therapeutic measures and appropriate disease monitoring of core binding factor acute myelogenous leukemia.
[Blood Cancer Journal]
Full Article
Bookmark

No account yet? Register

0
Share

3D Genome Alterations Associated with Dysregulated HOXA13 Expression in High-Risk T-Lineage Acute Lymphoblastic Leukemia

Investigators reported an integrated analysis of 3D genome alterations and differential gene expressions in eighteen newly diagnosed T-lineage acute lymphoblastic leukemia patients and four healthy controls. Patients with HOXA11-A13 expressions, but not other genes in the HOXA cluster, had immature immunophenotype and poor outcomes.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage Ambiguous Stem Cell Leukemia

The authors described a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
[Cancer Discovery]
Abstract
Bookmark

No account yet? Register

0
Share

Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50–75 Years of Age with Advanced Myelodysplastic Syndrome

Investigators conducted a multicenter biologic assignment trial comparing reduced-intensity hematopoietic cell transplantation to hypomethylating therapy or best supportive care in subjects 50-75 years of age with intermediate-2 or high-risk de novo myelodysplastic syndromes.
[Journal of Clinical Oncology]
Full Article
Bookmark

No account yet? Register

0
Share

Fanconi Anemia Proteins Participate in a Break-Induced-Replication-Like Pathway to Counter Replication Stress

Scientists showed that Fanconi anemia (FA)-mutated cells were hypersensitive to persistent replication stress and that FA proteins played a role in the break-induced-replication-like pathway for fork restart.
[Nature Structural & Molecular Biology]
Abstract
Bookmark

No account yet? Register

0
Share

Targeted PI3K/AKT-Hyperactivation Induces Cell Death in Chronic Lymphocytic Leukemia

Scientists hypothesized that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may have been leveraged to trigger chronic lymphocytic leukemia cell death.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

Interrogation of Novel CDK2/9 Inhibitor Fadraciclib (CYC065) as a Potential Therapeutic Approach for AML

In AML cell lines, myeloid cell leukemia 1 was downregulated following treatment with fadraciclib, resulting in a rapid induction of apoptosis.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

0
Share

Cabozantinib Promotes Erythroid Differentiation in K562 Erythroleukemia Cells through Global Changes in Gene Expression and JNK Activation

The authors reported that cabozantinib could promote differentiation in erythroid leukemia cells and found that K562 erythroid leukemia cells treated with 1 μM cabozantinib for 72 hours underwent erythroid lineage differentiation.
[Cancer Gene Therapy]
Abstract
Bookmark

No account yet? Register

0
Share

Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History

Researchers employed mitochondrial single-cell assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from nine patients with chronic lymphocytic leukemia collected across disease course and utilized mitochondrial DNA mutations as natural genetic markers of cancer clones.
[Cancer Discovery]
Abstract
Bookmark

No account yet? Register

0
Share

Depalmitoylation Rewires FLT3-ITD Signaling and Exacerbates Leukemia Progression

Investigators discovered that FLT3-ITD, one of the most frequent mutations in acute myeloid leukemia, was S-palmitoylated by the ZDHHC6 palmitoyl acyltransferase. Disruption of palmitoylation redirected FLT3-ITD to the plasma membrane and rewired its downstream signaling by activating AKT and ERK pathways in addition to STAT5.
[Blood]
Abstract
Bookmark

No account yet? Register

0
Share
Share