Allogeneic Stem Cell Transplantation for Patients with Aggressive NK-Cell Leukemia

Using the Japanese transplant registry data, the outcomes of 59 aggressive NK-cell leukemia patients who underwent first allogeneic hematopoietic stem cell transplantation were analyzed. Twenty-nine patients received stem cells from cord blood, 18 from peripheral blood, and 12 from bone marrow.
[Bone Marrow Transplantation]
Fujimoto, A., Ishida, F., Izutsu, K., Yamasaki, S., Chihara, D., Suzumiya, J., Mitsui, T., Doki, N., Sakai, H., Kobayashi, H., Kanda, J., Fukuda, T., Atsuta, Y., & Suzuki, R. (2020). Allogeneic stem cell transplantation for patients with aggressive NK-cell leukemia. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01009-8 Cite
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Unrelated Cord Blood Transplantation with Myeloablative Conditioning for Pediatric Acute Lymphoblastic Leukemia in Remission: Prognostic Factors

In the total patient cohort, five-year leukemia-free survival and overall survival rates after unrelated cord blood transplantation were 61.1% and 67.7%, respectively.
[Bone Marrow Transplantation]
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Hemogenyx Partners with UPenn to Study CAR T-Cell Therapy in AML

Hemogenyx Pharmaceuticals has inked a research agreement with the University of Pennsylvania (UPenn) for its CAR T-cell therapy for acute myeloid leukemia (AML).
[Hemogenyx Pharmaceuticals (Precision Oncology News)]
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The Role of Mitochondrial Proteases in Leukemic Cells and Leukemic Stem Cells

Investigators highlight the functional consequences of inhibiting and activating mitochondrial proteases and discuss their potential as therapeutic targets in acute myeloid leukemia.
[Stem Cells Translational Medicine]
Mirali, S., & Schimmer, A. D. (n.d.). The role of mitochondrial proteases in leukemic cells and leukemic stem cells. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0142 Cite
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BryoLogyx Announces Cooperative Research and Development Agreement for Bryostatin-1 with National Cancer Institute

BryoLogyx, Inc. announced that it has entered into a Cooperative Research and Development Agreement with the National Cancer Institute, to conduct a Phase I clinical trial with bryostatin-1 in pediatric and young adult patients with relapsing or refractory CD22 expressing acute lymphoblastic leukemia and lymphoma.
[BryoLogyx, Inc.]
Press Release

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Chromatin Accessibility Landscape of Pediatric T-Lymphoblastic Leukemia and Human T-Cell Precursors

Developmental stages were distinguished by 2,823 signature chromatin regions with 95% accuracy. Open chromatin surrounding SAE 1 was identified to best distinguish thymic developmental stages suggesting a potential role of SUMO ylation in T‐cell development.
[EMBO Molecular Medicine]
Erarslan-Uysal, B., Kunz, J. B., Rausch, T., Richter-Pechańska, P., van Belzen, I. A., Frismantas, V., Bornhauser, B., Ordoñez-Rueada, D., Paulsen, M., Benes, V., Stanulla, M., Schrappe, M., Cario, G., Escherich, G., Bakharevich, K., Kirschner-Schwabe, R., Eckert, C., Loukanov, T., Gorenflo, M., … Kulozik, A. E. (2020). Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors. EMBO Molecular Medicine, n/a(n/a), e12104. https://doi.org/10.15252/emmm.202012104 Cite
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Prostaglandin E2 Stimulates cAMP Signaling and Re-Sensitizes Human Leukemia Cells to Glucocorticoid-Induced Cell Death

To identify glucocorticoid resistance pathways, investigators conducted a genome-wide, survival-based, shRNA screen in murine T cell acute lymphoblastic leukemia cells.
[Blood]
Roderick, J. E., Gallagher, K. M., Murphy, L. C., O’Connor, K. W., Tang, K., Zhang, B., Brehm, M., Greiner, D. L., Yu, J., Zhu, L. J., Green, M. R., & Kelliher, M. A. (n.d.). Prostaglandin E2 stimulates cAMP signaling and re-sensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. https://doi.org/10.1182/blood.2020005712 Cite
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The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia: A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Two consecutive international prospective studies, ALL- stem cell transplantation (SCT)-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with very high risk disease leading to any kind of hematopoietic SCT.
[Bone Marrow Transplantation]
Dalle, J.-H., Balduzzi, A., Bader, P., Pieczonka, A., Yaniv, I., Lankester, A., Bierings, M., Yesilipek, A., Sedlacek, P., Ifversen, M., Svec, P., Toporski, J., Gungor, T., Wachowiak, J., Glogova, E., Poetschger, U., & Peters, C. (2020). The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01014-x Cite
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Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation for Mature T- and NK-Cell Neoplasms in the Kyoto Stem Cell Transplantation Group

39 patients received bone marrow or peripheral blood stem cell transplantation from related donors, 37 received BMT/PBSCT from unrelated donors, and 35 received cord blood transplantation
[Biology of Blood and Marrow Transplantation]
Watanabe, M., Kanda, J., Arai, Y., Hishizawa, M., Nishikori, M., Ishikawa, T., Imada, K., Ueda, Y., Akasaka, T., Yonezawa, A., Nohgawa, M., Kitano, T., Itoh, M., Takeoka, T., Moriguchi, T., Yago, K., Arima, N., Anzai, N., Watanabe, M., … Takaori-Kondo, A. (2020). Impact of donor source on allogeneic hematopoietic stem cell transplantation for mature T- and NK-cell neoplasms in the Kyoto Stem Cell Transplantation Group. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.07.032 Cite
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Prognostic Impact of TP53 Mutation, Monosomal Karyotype, and Prior Myeloid Disorder in Nonremission Acute Myeloid Leukemia at allo-HSCT

Researchers analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors for predicting overall survival at one month before transplantation. They enrolled 120 patients with nonremission acute myeloid leukemia who underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2005 and 2018.
[Bone Marrow Transplantation]
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LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Researchers showed that LW-213 dose-dependently inhibited human cutaneous T-cell lymphoma cell lines with IC50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients.
[Acta Pharmacologica Sinica]
Yu, X., Zhu, M., Wang, J., Li, H., Hu, P., Qing, Y., Wang, X., Wang, H., Wang, Z., Xu, J., Guo, Q., & Hui, H. (2020). LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0466-7 Cite
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Clonal Hematopoiesis in the Inherited Bone Marrow Failure Syndromes

Scientists describe a framework by which an understanding of the processes that promote clonal hematopoiesis in inherited bone marrow failure syndromes may inform clinical surveillance strategies.
[Blood]
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