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leukemia

Century Therapeutics and Bristol Myers Squibb Enter into a Strategic Collaboration to Develop iPSC-Derived Allogeneic Cell Therapies

[Century Therapeutics] Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.

SCP4-STK35/PDIK1L Complex Is a Dual Phospho-Catalytic Signaling Dependency in Acute Myeloid Leukemia

[Cell Reports] Investigators showed that STK35 and PDIK1L function catalytically and redundantly in the same pathway as SCP4 to maintain acute myeloid leukemia proliferation and to support amino acid biosynthesis and transport.

Bone Mesenchymal Stem Cell-Derived Exosomal microRNA-7-5p Inhibits Progression of Acute Myeloid Leukemia by Targeting OSBPL11

[Journal of Nanobiotechnology] Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.

Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia

[Frontiers in Oncology] The authors report on mechanism of action, safety, and efficacy data on combination strategies based on hypomethylating agents in the setting of post-allogeneic stem cell transplant relapse.

Use of CAR T Cell for Acute Lymphoblastic Leukemia (ALL) Treatment: A Review Study

[Cancer Gene Therapy] Scientists discuss different generations, challenges, and clinical studies related to chimeric antigen receptor (CAR) T cells for ALL treatment.

Rafael Pharmaceuticals Announces Successful Completion of Dose Escalation with No Dose-Limiting Toxicity (DLT) in First Cohort of APOLLO 613 Phase I/II Clinical Trial of...

[Rafael Pharmaceuticals, Inc. (Globe Newswire, Inc.)] Rafael Pharmaceuticals, Inc. announced the completion of the first cohort of dose escalation with no DLT in the APOLLO 613 Phase I/II clinical trial of devimistat in combination with hydroxychloroquine in patients with relapsed clear cell sarcoma.

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