Tag Archives: leukemia

GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
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Fate Therapeutics Announces FDA Clearance of IND Application for First-Ever iPSC-derived CAR T-Cell Therapy

Fate Therapeutics, Inc. announced that the FDA has cleared the company’s Investigational New Drug application for FT819, an off-the-shelf allogeneic chimeric antigen receptor T-cell therapy targeting CD19+ malignancies.
[Fate Therapeutics, Inc.]
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Signal-Transducing Adapter Protein-1 Is Required for Maintenance of Leukemic Stem Cells in CML

Scientists found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.
[Oncogene]
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Immunogenomic Landscape of Hematological Malignancies

Researchers integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally.
[Cancer Cell]
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Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice

Humanized mice allow in vivo characterization of the engraftment and differentiation capacities of hematopoietic stem/progenitor cell subpopulations, as well as the functional discrimination of normal and malignant stem cells.
[Trends in Immunology]
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Chromosomal Alterations among Age-Related Hematopoietic Clones in Japan

Scientists describe shared and population-specific patterns of genomic mutations and clonal selection in hematopoietic cells on the basis of 33,250 autosomal mosaic chromosomal alterations that they detected in 179,417 Japanese participants in the BioBank Japan cohort and compared with analogous data from the UK Biobank.
[Nature]
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MLLT10 in Benign and Malignant Hematopoiesis

The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
[Experimental Hematology]
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Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations

The authors established an efficient CRISPR/Cas9-based mixed lineage leukemia rearrangements model in hematopoietic stem and progenitor cells (HSPCs) derived from human cord blood (huCB) and faithfully mimicked the underlying biology of the disease. They applied this model to HSPCs from adult bone marrow to investigate the impact of the cell of origin and fusion partner on disease development.
[Cancers]
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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

Researchers showed integrin-linked kinase, a key constituent of focal adhesions, is highly expressed in TKI-nonresponsive patient cells and their LSCs.
[Cell Stem Cell]
Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R. C., & Challen, G. A. (2020). Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.02.011 Cite
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