leukemia

[Pediatric Research] The authors evaluated the prognostic value of Sal-like protein 4 transcription factor (SALL4) and B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in children with acute lymphoblastic leukemia.

[Cell Death & Disease] Researchers investigated the mechanism by which nucleolar and spindle-associated protein 1 enhanced chemoresistance via DNA damage repair signaling by stabilizing RAD51 in chronic lymphocytic leukemia cells.

[Modern Pathology] Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.

[Laboratory Investigation] Scientists explored putative mechanisms of microRNA-155-5p involvement in childhood acute lymphoblastic leukemia via interactions with casitas B-lineage lymphoma (CBL), interferon regulatory factor 4 (IRF4), and cyclin-dependent kinase 6 (CDK6).

[Bone Marrow Transplantation] Investigators suggested that almost 80% of acute myeloid leukemia patients could undergo salvage therapy following relapse after front-line high-dose chemotherapy/autologous hematopoietic cell transplantation.

[Cancer Discovery] The authors presented a humanized animal model of myelofibrosis patient-derived xenografts which were robustly engrafted patient cells that recapitulated the patient's genetic hierarchy and pathologies such as reticulin fibrosis and propagation of myeloproliferative neoplasms-initiating stem cells.