Targeted therapy has markedly improved outcomes for pediatric chronic myelogenous leukemia, while raising a number of clinical questions, including the possibility of treatment-free remission and long-term health implications of prolonged tyrosine kinase inhibitors exposure at a young age.
[Current Oncology Reports]
The Acute Leukemia Working Party/European Society for Blood and Marrow Transplantation registry was used to evaluate the outcomes of adult patients with acute lymphoblastic leukemia who underwent hematopoietic cell transplantation during 2011 through 2015 and compared them with the outcomes of those who underwent transplantation during 2016 through 2018.
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Nagler, A., Labopin, M., Koc, Y., Angelucci, E., Tischer, J., Arat, M., Pioltelli, P., Bernasconi, P., Chiusolo, P., Diez‐Martin, J. L., Sanz, J., Ciceri, F., Peric, Z., Giebel, S., Canaani, J., & Mohty, M. (n.d.). Outcome of T-cell–replete haploidentical stem cell transplantation improves with time in adults with acute lymphoblastic leukemia: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Cancer, n/a(n/a). https://doi.org/https://doi.org/10.1002/cncr.33522 Cite
Scientists analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo acute myeloid leukemia.
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Kaburagi, T., Yamato, G., Shiba, N., Yoshida, K., Hara, Y., Tabuchi, K., Shiraishi, Y., Ohki, K., Sotomatsu, M., Arakawa, H., Matsuo, H., Shimada, A., Taki, T., Kiyokawa, N., Tomizawa, D., Horibe, K., Miyano, S., Taga, T., Adachi, S., … Hayashi, Y. (2020). Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia. Haematologica. https://doi.org/10.3324/haematol.2020.269431 Cite
A Phase II study of acalabrutinib was conducted in patients with relapsed/refractory chronic lymphocytic leukemia who were ibrutinib-intolerant and had continued disease activity.
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Rogers, K. A., Thompson, P. A., Allan, J. N., Coleman, M., Sharman, J. P., Cheson, B. D., Jones, D., Izumi, R., Frigault, M. M., Quah, C., Raman, R. K., Patel, P., Wang, M. H., & Kipps, T. J. (2020). Phase 2 study of acalabrutinib in ibrutinib-intolerant patients with relapsed/refractory chronic lymphocytic leukemia. Haematologica. https://doi.org/10.3324/haematol.2020.272500 Cite
Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
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The authors investigated B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) expression in brain tumors using microarray datasets in ONCOMINE, which indicated that BMI1 levels were not commonly increased in clinical brain tumors.
[Biochemical and Biophysical Research Communications]
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Flow cytometry analyses revealed a higher EOMES expression in CD8+ T cells of chronic lymphocytic leukemia (CLL) patients compared to healthy individuals, and an accumulation of PD-1+ EOMES+ CD8+ T cells in lymph nodes rather than blood or bone marrow in CLL.
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Llaó-Cid, L., Roessner, P. M., Chapaprieta, V., Öztürk, S., Roider, T., Bordas, M., Izcue, A., Colomer, D., Dietrich, S., Stilgenbauer, S., Hanna, B., Martín-Subero, J. I., & Seiffert, M. (2021). EOMES is essential for antitumor activity of CD8 + T cells in chronic lymphocytic leukemia. Leukemia, 1–11. https://doi.org/10.1038/s41375-021-01198-1 Cite
The authors report that trisomy 12 (tri12) human pluripotent stem cells (PSCs) allowed for the identification of gene networks and targets specific to tri12, which are controlled by comparative normal PSCs.
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Reid, J. C., Golubeva, D., Boyd, A. L., Hollands, C. G., Henly, C., Orlando, L., Leber, A., Hébert, J., Morabito, F., Cutrona, G., Agnelli, L., Gentile, M., Ferrarini, M., Neri, A., Leber, B., & Bhatia, M. (2021). Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients. Cell Reports, 34(11). https://doi.org/10.1016/j.celrep.2021.108845 Cite
Genetic attenuation or pharmacological inhibition of VLCAD hindered mitochondrial respiration and fatty acid oxidation contribution to the TCA cycle, resulting in decreased viability, proliferation, clonogenic growth and acute myeloid leukemia cell engraftment.
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Tcheng, M., Roma, A., Ahmed, N., Smith, R. W., Dr, Jayanth, P., Minden, M. D., Schimmer, A. D., Hess, D. A., Hope, K., Akhtar, T., Bohrnsen, E., D’Alessandro, A., Mohsen, A.-W., Vockley, J., & Spagnuolo, P. A. (2021). Very long chain fatty acid metabolism is required in acute myeloid leukemia. Blood, blood.2020008551. https://doi.org/10.1182/blood.2020008551 Cite
Researchers established a stringent flow cytometric protocol for the prospective isolation of a CD73+ CD105+ CD271+ bone marrow (BM) stromal cell subpopulation from uncultivated cryopreserved BM of myelodysplastic syndrome and acute myeloid leukemia patients as well as age-matched healthy donors.
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PI3K∂ blockade by idelalisib reduced the expression levels of inhibitory checkpoint molecules in T cells isolated from both healthy donors and chronic lymphocytic leukemia patients.
[Frontiers in Immunology]
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