leukemia

[Nature Communications] Scientists showed that human T cells engineered to express an mLPA-specific TCR, targeted diverse CD1c-expressing leukemia blasts in vitro and significantly delayed the progression of three models of leukemia xenograft in NSG mice, an effect that was boosted by mLPA-cellular immunization.

[Science Advances] Researchers found that the levels of the histone acetyltransferase males absent on the first and its target modification histone H4 lysine 16 acetylation were heterogeneous among HSCs and influenced their proliferation capacities.

[Leukemia] Using a mouse model with a gain-of-function CXCR4 mutation that hyperactivated CXCR4 signaling, scientists identified CXCR4 as a crucial activator of multiple key oncogenic pathways.

[Leukemia] Using a sphingolipid network focused CRISPR/Cas9 library screen, scientists identified an endoplasmic reticulum enzyme, 3-Ketodihydrosphingosine reductase, to be essential for leukemia cell maintenance.

[Cell Metabolism] Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.

[Blood] Scientists demonstrated that conditional deletion of acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) in hematopoietic cells impaired repopulation capacity and post-injury regeneration of HSCs.