Determinants and Role of Chromatin Organization in Acute Leukemia

The authors provide detailed discussion of the nature of 3D interactions and the way that they are disrupted in acute leukemia.
[Leukemia]
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Therapeutic Inhibition of FcγRIIb Signaling Targets Leukemic Stem Cells in Chronic Myeloid Leukemia

Scientists describe the immunoreceptor tyrosine-based inhibition motif-containing Fc gamma receptor IIb for being critical in leukemic stem cell resistance and showed that targeting FcγRIIb downstream signaling, by using a Food and Drug Administration-approved BTK inhibitor, provides a successful therapeutic approach.
[Leukemia]
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β-Catenin Safeguards the Ground State of Mouse Pluripotency by Strengthening the Robustness of the Transcriptional Apparatus

Scientists showed that β-catenin, stabilized by GSK3 inhibition in medium with 2i, supplied transcriptional coregulators at pluripotency loci. This selectively strengthened pluripotency loci and rendered them addicted to transcription initiation for productive gene body elongation in detriment to promoter-proximal paused RNA polymerase II pause release.
[Science Advances]
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DDX5-Targeting Fully Human Monoclonal Autoantibody Inhibits Proliferation and Promotes Differentiation of Acute Promyelocytic Leukemia Cells by Increasing ROS Production

2F5 was confirmed to induce G0/G1 phase arrest in acute promyelocytic leukemia (APL) cells, and promoted APL cell differentiation combined with decreased DDX5 expression and increased reactive oxygen species production. Knockdown of DDX5 by siRNA also inhibited proliferation, promoted cell differentiation and enhanced ROS production in APL cells.
[Cell Death & Disease]
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Endogenous Retroviruses Are a Source of Enhancers with Oncogenic Potential in Acute Myeloid Leukemia

The authors identified six endogenous retrovirus families with acute myeloid leukemia (AML)-associated enhancer chromatin signatures that are enriched in binding of key regulators of hematopoiesis and AML pathogenesis.
[Nature Communications]
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GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
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Fate Therapeutics Announces FDA Clearance of IND Application for First-Ever iPSC-derived CAR T-Cell Therapy

Fate Therapeutics, Inc. announced that the FDA has cleared the company’s Investigational New Drug application for FT819, an off-the-shelf allogeneic chimeric antigen receptor T-cell therapy targeting CD19+ malignancies.
[Fate Therapeutics, Inc.]
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Signal-Transducing Adapter Protein-1 Is Required for Maintenance of Leukemic Stem Cells in CML

Scientists found that the expression of STAP-1 was aberrantly upregulated in chronic myeloid leukemia (CML) stem cells in patients’ bone marrow.
[Oncogene]
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Immunogenomic Landscape of Hematological Malignancies

Researchers integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally.
[Cancer Cell]
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Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice

Humanized mice allow in vivo characterization of the engraftment and differentiation capacities of hematopoietic stem/progenitor cell subpopulations, as well as the functional discrimination of normal and malignant stem cells.
[Trends in Immunology]
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Chromosomal Alterations among Age-Related Hematopoietic Clones in Japan

Scientists describe shared and population-specific patterns of genomic mutations and clonal selection in hematopoietic cells on the basis of 33,250 autosomal mosaic chromosomal alterations that they detected in 179,417 Japanese participants in the BioBank Japan cohort and compared with analogous data from the UK Biobank.
[Nature]
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