leukemia

[BMC Medicine] Patients’ gene expression profile from seven GEO databases was normalized after removing the batch effect. Tumor immune microenvironment (TIME) cell components were explored through Xcell tools and then hierarchically clustered to establish TIME classification.

[Scientific Reports] The authors developed an in vitro cell model in which human acute lymphoblastic leukemia cells were grown in co-culture with human derived bone marrow stromal cells or osteoblasts to interrogate a clinically relevant population of treatment refractory cells.

[Molecular Cell] ZMYND8 was essential for acute myeloid leukemia proliferation in vitro and in vivo and associated with MYC and IRF8 enhancer elements that researchers defined in cell lines and in patient samples.

[Blood Cancer Journal] The authors studied spike-specific antibody responses following first and/or second COVID-19 vaccination in 299 patients with chronic lymphocytic leukemia compared with healthy donors.

[Leukemia] Treatment of human acute myeloid leukemia (AML) cells with a PAICS inhibitor suppressed their proliferation by inhibiting DNA synthesis and promoting apoptosis and had anti-leukemic effects in AML PDX models.

[Leukemia] Loss of both SHMT1 and SHMT2 was necessary for impaired growth and cell cycle arrest, with suppression of both SHMT1 and SHMT2 inhibiting leukemia progression in vivo.