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leukemia

Nuclear NAD+ Homeostasis Governed by NMNAT1 Prevents Apoptosis of Acute Myeloid Leukemia Stem Cells

[Science Advances] Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.

Increase in Polymorphonuclear Myeloid-Derived Suppressor Cells and Regulatory T-Cells in Children with B-Cell Acute Lymphoblastic Leukemia

[Scientific Reports] Scientists observed a reduction in the levels of CD4+ T cells and an increase in both the polymorphonuclear MDSCs and Tregs.

Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis

[Cell Stem Cell] Investigators performed a metabolic drug screen to identify leukemic stem cell (LSC)-specific vulnerabilities and found that nicotinamide phosphoribosyltransferase inhibitors selectively killed LSCs, while sparing normal hematopoietic stem and progenitor cells.

Lysine Acetylation Restricts Mutant IDH2 Activity to Optimize Transformation in AML Cells

[Molecular Cell] Mutant IDH2 (mIDH2) R140Q commonly had K413 acetylation, which negatively regulated mIDH2 activity in human acute myeloid leukemia (AML) cells by attenuating dimerization and blocking binding of substrate (α-ketoglutarate) and cofactor (NADPH).

miR-181c Regulates MCL1 and Cell Survival in GATA2 Deficient Cells

[Journal of Leukocyte Biology] miRNA profiles were evaluated and eight miRNAs were found to be differentially expressed in patient-derived cell lines in comparison to controls. miR-181c was predicted to target myeloid cell leukemia (MCL)1, which was confirmed by transfection assays, resulting in significantly reduced MCL1 mRNA and decreased live cell numbers.

Curcumin Attenuates Adriamycin-Resistance of Acute Myeloid Leukemia by Inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 Axis

[Laboratory Investigation] Scientists investigated the mechanism by which curcumin affected the resistance of acute myeloid leukemia to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.

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