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leukocytes

Virus Induced Lymphocytes (VIL) as a Novel Viral Antigen-Specific T Cell Therapy for COVID-19 and Potential Future Pandemics

[Scientific Reports] Using a novel SARS-Cov-2-specific artificial antigen presenting cell, coupled with a rapid expansion protocol as practiced in tumor infiltrating lymphocytes therapy, researchers generated an immune catalytic quantity of VIL.

Plasma Extracellular Vesicle Delivery of miR-210-3p by Targeting ATG7 to Promote Sepsis-Induced Acute Lung Injury by Regulating Autophagy and Activating Inflammation

[Experimental & Molecular Medicine] Scientists elucidated the role of plasma extracellular vesicles in delivering miR-210-3p in sepsis-induced acute lung injury.

Single-Cell RNA Sequencing Reveals Ex Vivo Signatures of SARS-CoV-2-Reactive T Cells through ‘Reverse Phenotyping’

[Nature Communications] Investigators used single-cell RNA sequencing to identify and profile SARS-CoV-2-reactive T cells from COVID-19 patients.

Pro-Resolving Lipid Mediators: Regulators of Inflammation, Metabolism and Kidney Function

[Nature Reviews Nephrology] In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis.

Phenotype, Specificity and Avidity of Antitumour CD8+ T Cells in Melanoma

[Nature] Scientists showed, by linking the antigenic specificity of TCRs and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumor specificity shaped the expression state of intratumoural CD8+ T cells.

Alternative Pathways for the Development of Lymphoid Structures in Humans

[Proceedings of the National Academy of Sciences of the United States of America] In humans, JAK3 and γc deficiencies resulted in severe combined immunodeficiency characterized by an absence of T cells, natural killer cells, innate lymphoid cells, and presumably lymphoid tissue inducer cells.

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