leukocytes

[Life Sciences] The authors summarize the current knowledge on the cardiac signaling pathways modulated by two antineoplastic drugs highly used in the management of breast cancer, not only focusing on cardiomyocytes but also to broaden the knowledge of the potential impact on other cells found in the heart.

[Seminars in Cell & Developmental Biology] The authors present the interactions that leukocytes develop with the cells present in their vicinity, such as the activation of muscle stem cells and the maturation of newly formed myofibers, and the impact they have on skeletal muscle regeneration.

[Nature Reviews Drug Discovery] The authors summarize key discoveries that aid the clinical translation of PI3Kα and PI3Kδ inhibitors, including the PI3Kα isoform-selective inhibitor alpelisib for the treatment of breast cancer, highlighting lessons learnt and future opportunities.

[Scientific Reports] Scientists showed acquired Parkin and AMPK deficiency in leukocytes of post-sepsis immunosuppression from human subjects and mice.

[Cancer Immunology Research] Researchers found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells.

[Nature] Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.