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leukocytes

Label-Free Enrichment of MCF7 Breast Cancer Cells from Leukocytes Using Continuous Flow Dielectrophoresis

[Electrophoresis] Scientists presented a continuous flow, antibody-free dielectrophoresis-based microfluidic device to concentrate MCF7 breast cancer cells, a well-established circulating tumor cells model, in the presence of leukocytes extracted from human blood samples.

Endothelial Pannexin-1 Channels Modulate Macrophage and Smooth Muscle Cell Activation in Abdominal Aortic Aneurysm Formation

[Nature Communications] Pannexin-1 on endothelial cells acted as a conduit for ATP release that stimulated macrophage activation via P2X7 receptors and mitochondrial DNA release to increase IL-1β and HMGB1 secretion.

In Situ Imaging for Tumor Microbiome Interactions via Imaging Mass Cytometry on Single-Cell Level

[Cytometry Part A] Researchers developed a rapid semi-quantitative method for in situ imaging of bacteria and multiplex cell phenotypes on the same solid tumor tissue sections.

ACE2-Independent Infection of T Lymphocytes by SARS-CoV-2

[Signal Transduction and Targeted Therapy] Scientists confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells or postmortem lung T cells, and the infectious virus could also be detected from viral antigen-positive PBCs.

Emerging Enterococcus Pore-Forming Toxins with MHC/HLA-I as Receptors

[Cell] Scientists identified a family of Enterococcus pore-forming toxins in E. faecalis, E. faecium, and E. hirae strains isolated across the globe.

KIR+CD8+ T Cells Suppress Pathogenic T Cells and Are Active in Autoimmune Diseases and COVID-19

[Science] CD8+ T expressing inhibitory killer cell immunoglobulin-like receptors cells efficiently eliminated pathogenic gliadin-specific CD4+ T cells from celiac disease patients’ leukocytes in vitro.

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