Prenatal Exposure to Poly-/Per-Fluoroalkyl Substances Is Associated with Alteration of Lipid Profiles in Cord-Blood

Researchers combined determination of bile acids and molecular lipids by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified cord blood concentrations of sixteen poly-/per-fluoroalkyl substances in a cohort of Chinese infants in a cross-sectional study.
[Metabolomics]
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Interactions between Gastric Microbiota and Metabolites in Gastric Cancer

Scientists characterized the gastric microbiome and metabolome profiles of 37 gastric cancer tumor tissues and matched non-tumor tissues using 16s rRNA gene sequencing and ultrahigh performance liquid chromatography tandem mass spectrometry, respectively.
[Cell Death & Disease]
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Improving Motor Neuron-Like Cell Differentiation of hEnSCs by the Combination of Epothilone B Loaded PCL Microspheres in Optimized 3D Collagen Hydrogel

Providing a 3D permissive environment with epothilone B significantly improved motor neuron-like cell differentiation and maturation of human endometrial stem cells (hEnSCs) and was a promising approach to replace lost neurons after spinal cord injury.
[Scientific Reports]
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Flavonoids Derived from Anemarrhenae Rhizoma Ameliorate Inflammation of Benign Prostatic Hyperplasia via Modulating COX/LOX Pathways

Scientists reported that Anemarrhenae Rhizoma flavonoids inhibited benign prostatic hyperplasia-related inflammation in vivo and in vitro by targeting arachidonic acid metabolism and interfering with cyclooxygenase (COX) and lipoxygenase (LOX) pathways.
[Journal of Ethnopharmacology]
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Metabolomics and Cytokine Profiling of Mesenchymal Stromal Cells Identify Markers Predictive of T-Cell Suppression

The authors provided a platform for identifying markers for predicting MSC functional capacity using partial least squares regression modeling that could be used as release criteria and guide future manufacturing strategies for mesenchymal stromal cells and other cell therapies.
[Cytotherapy]
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Antiproliferative, Proapoptotic, and Tumor-Suppressing Effects of the Novel Anticancer Agent Alsevirone in Prostate Cancer Cells and Xenografts

Investigators explored the mechanisms of action of alsevirone in prostate cancer in vitro and in vivo: CYP17A1 inhibition, cytotoxic, apoptotic, and antitumor effects compared with abiraterone.
[Archiv Der Pharmazie]
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Stimulation of Motilin Secretion by Bile, Free Fatty Acids and Acidification in Human Duodenal Organoids

Human duodenal organoids were CRISPR-Cas9 modified to express the fluorescent protein Venus or the Ca2+ sensor GCaMP7s under control of the endogenous motilin promoter.
[Molecular Metabolism]
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The Proteomic Architecture of Schizophrenia iPSC-Derived Cerebral Organoids Reveals Alterations in GWAS and Neuronal Development Factors

Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.
[Translational Psychiatry]
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Comparison of the Blood, Bone Marrow, and Cerebrospinal Fluid Metabolomes in Children with B Cell Acute Lymphoblastic Leukemia

Researchers profiled end-induction plasma, marrow, and cerebrospinal fluid (CSF) from ten children with b-cell acute lymphoblastic leukemia using liquid chromatography-mass spectrometry and observed plasma-marrow correlations for metabolites in pathways associated with end-induction residual disease and plasma-CSF correlations for a biomarker of fatigue.
[Scientific Reports]
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Antiproliferative Activity of Aqueous and Polyphenol-Rich Extracts of Larrea divaricata Cav. on a Melanoma Cell Line

The effects of Larrea divaricata, polyphenols and quercetin-3-methyl ether were assessed on B16F10 melanoma cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3.
[Natural Product Research]
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Comprehensive Polar Metabolomics and Lipidomics Profiling Discriminates the Transformed from the Non-transformed State in Colon Tissue and Cell Lines

Researchers performed untargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry-based polar metabolomics and lipidomics to non-transformed and transformed colon cell lines as well as tissue samples from ten colorectal cancer patients.
[Scientific Reports]
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