Investigators developed two hiPSC/hESC-specific glycan-recognizing mouse antibodies, R-10G and R-17F, using the Tic hiPSC line as an antigen. R-10G recognized a low-sulfate keratan sulfate, and R-17F recognized lacto-N-fucopentaose-1.
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Collection of an adequate number of PDAC cells is difficult due to the surrounding fibroblasts. The authors discovered novel biomarkers to predict chemosensitivity based on the collagen gel droplet-embedded drug sensitivity test results.
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Mitachi, K., Ariake, K., Shima, H., Sato, S., Miura, T., Maeda, S., Ishida, M., Mizuma, M., Ohtsuka, H., Kamei, T., Igarashi, K., & Unno, M. (2021). Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer. Scientific Reports, 11(1), 6541. https://doi.org/10.1038/s41598-021-86099-0 Cite
Researchers investigated intra-cellular lipid disturbances induced by adenomatous polyposis coli (APC) gene mutations in intestinal organoids using a reversed-phase ultra-high-performance liquid chromatography mass spectrometry-based lipid profiling method.
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Scientists surveyed and characterized the molecular changes induced by PANX1 re-expression in rhabdomyosarcoma. They cataloged transcriptomic changes in this context by RNA sequencing.
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Xiang, X., Langlois, S., St-Pierre, M.-E., Blinder, A., Charron, P., Graber, T. E., Fowler, S. L., Baird, S. D., Bennett, S. A. L., Alain, T., & Cowan, K. N. (2021). Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01623-2 Cite
Scientists demonstrated that electromembrane extraction based on electrophoresis across an oil membrane was suited for segregating selected organoid-derived drug metabolites prior to mass spectrometry-based measurements.
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Skottvoll, F. S., Hansen, F. A., Harrison, S., Boger, I. S., Mrsa, A., Restan, M. S., Stein, M., Lundanes, E., Pedersen-Bjergaard, S., Aizenshtadt, A., Krauss, S., Sullivan, G., Bogen, I. L., & Wilson, S. R. (2021). Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.0c05082 Cite
Data from liquid chromatography-mass spectrometry and microscale thermophoresis informed the development of a novel antibody to inhibit platelet-endothelial adhesion, which was tested in cells from chronic thromboembolic pulmonary hypertension patients and three animal models in vivo.
[American Journal of Respiratory and Critical Care Medicine]
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Alba, G. A., Samokhin, A. O., Wang, R.-S., Zhang, Y.-Y., Wertheim, B. M., Arons, E., Greenfield, E. A., Lundberg Slingsby, M. H., Ceglowski, J. R., Haley, K. J., Bowman, F. P., Yu, Y.-R., Haney, J. C., Eng, G., Mitchell, R. N., Sheets, A., Vargas, S. O., Seo, S., Channick, R. N., … Maron, B. A. (2021). NEDD9 is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202003-0719OC Cite
Scientists report that eukaryotic protein translation elongation factor 1α2 (EEF1A2) mediates the epithelial–mesenchymal transformation, to promote the metastasis of lung adenocarcinoma cells in vitro and in vivo.
[British Journal of Cancer]
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Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
[Cell Death & Disease]
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Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
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Seiser, S., Janker, L., Zila, N., Mildner, M., Rakita, A., Matiasek, J., Bileck, A., Gerner, C., Paulitschke, V., & Elbe-Bürger, A. (2021). Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin. Scientific Reports, 11(1), 32. https://doi.org/10.1038/s41598-020-79378-9 Cite
Scientists caracterized the effect of bile acidson carcinogenic processes using PDAC cell lines and to investigate the underlying mechanisms. Liquid chromatography-mass spectrometry was used to determine the serum concentrations of bile acids.
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Gál, E., Veréb, Z., Kemény, L., Rakk, D., Szekeres, A., Becskeházi, E., Tiszlavicz, L., Takács, T., Czakó, L., Hegyi, P., & Venglovecz, V. (2020). Bile accelerates carcinogenic processes in pancreatic ductal adenocarcinoma cells through the overexpression of MUC4. Scientific Reports, 10(1), 22088. https://doi.org/10.1038/s41598-020-79181-6 Cite