EEF1A2 Interacts with HSP90AB1 to Promote Lung Adenocarcinoma Metastasis via Enhancing TGF-β/SMAD Signaling

Scientists report that eukaryotic protein translation elongation factor 1α2 (EEF1A2) mediates the epithelial–mesenchymal transformation, to promote the metastasis of lung adenocarcinoma cells in vitro and in vivo.
[British Journal of Cancer]
Jia, L., Ge, X., Du, C., Chen, L., Zhou, Y., Xiong, W., Xiang, J., Li, G., Xiao, G., Fang, L., & Li, Z. (2021). EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-020-01250-4 Cite
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Isolation and Purification of Glycoglycerolipids To Induce Apoptosis in Breast Cancer Cells

Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
[Scientific Reports]
Abedin, M. R., & Barua, S. (2021). Isolation and purification of glycoglycerolipids to induce apoptosis in breast cancer cells. Scientific Reports, 11(1), 1298. https://doi.org/10.1038/s41598-020-80484-x Cite
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ACPA Decreases Non-Small Cell Lung Cancer Line Growth through Akt/PI3K and JNK Pathways In Vitro

Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
[Cell Death & Disease]
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Octenidine-Based Hydrogel Shows Anti-Inflammatory and Protease-Inhibitory Capacities in Wounded Human Skin

Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
[Scientific Reports]
Seiser, S., Janker, L., Zila, N., Mildner, M., Rakita, A., Matiasek, J., Bileck, A., Gerner, C., Paulitschke, V., & Elbe-Bürger, A. (2021). Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin. Scientific Reports, 11(1), 32. https://doi.org/10.1038/s41598-020-79378-9 Cite
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Bile Accelerates Carcinogenic Processes in Pancreatic Ductal Adenocarcinoma Cells through the Overexpression of MUC4

Scientists caracterized the effect of bile acidson carcinogenic processes using PDAC cell lines and to investigate the underlying mechanisms. Liquid chromatography-mass spectrometry was used to determine the serum concentrations of bile acids.
[Scientific Reports]
Gál, E., Veréb, Z., Kemény, L., Rakk, D., Szekeres, A., Becskeházi, E., Tiszlavicz, L., Takács, T., Czakó, L., Hegyi, P., & Venglovecz, V. (2020). Bile accelerates carcinogenic processes in pancreatic ductal adenocarcinoma cells through the overexpression of MUC4. Scientific Reports, 10(1), 22088. https://doi.org/10.1038/s41598-020-79181-6 Cite
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Metabolism and Pharmacokinetics of a Novel Polyphenol Fatty Acid Ester Phloridzin Docosahexaenoate in Balb/C Female Mice

Researchers report metabolites and pharmacokinetic parameters of phloridzin docosahexaenoate (PZ-DHA), determined using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. PZ-DHA was taken-up by human and mouse mammary carcinoma and human non-malignant mammary epithelial cells in cellular uptake assays.
[Scientific Reports]
Fernando, W., Goralski, K. B., Hoskin, D. W., & Rupasinghe, H. P. V. (2020). Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice. Scientific Reports, 10(1), 21391. https://doi.org/10.1038/s41598-020-78369-0 Cite
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Chemical Composition of Polish Propolis and Its Antiproliferative Effect in Combination with Bacopa monnieri on Glioblastoma Cell Lines

Researchers investigated the chemical composition of Polish propolis extract by gas chromatography-mass spectrometry, B. monnieri extracts (BcH, BcS) by high performance liquid chromatography with diode array detector and mass spectrometry coupled with electrospray ionization and finally determine its anti-proliferative potential combined with BcH and BcS in glioblastoma cell lines.
[Scientific Reports]
Moskwa, J., Naliwajko, S. K., Markiewicz-Żukowska, R., Gromkowska-Kępka, K. J., Nowakowski, P., Strawa, J. W., Borawska, M. H., Tomczyk, M., & Socha, K. (2020). Chemical composition of Polish propolis and its antiproliferative effect in combination with Bacopa monnieri on glioblastoma cell lines. Scientific Reports, 10(1), 21127. https://doi.org/10.1038/s41598-020-78014-w Cite
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Organoid Sample Preparation and Extraction for LC-MS Peptidomics

Scientists describe the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry.
[STAR Protocols]
Miedzybrodzka, E. L., Foreman, R. E., Galvin, S. G., Larraufie, P., George, A. L., Goldspink, D. A., Reimann, F., Gribble, F. M., & Kay, R. G. (2020). Organoid Sample Preparation and Extraction for LC-MS Peptidomics. STAR Protocols, 100164. https://doi.org/10.1016/j.xpro.2020.100164 Cite
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Spermine Promotes Pulmonary Vascular Remodelling and Its Synthase Is a Therapeutic Target for Pulmonary Arterial Hypertension

The roles of spermine and spermine synthase were examined in pulmonary arterial smooth muscle cells and rodent models of pulmonary hypertension.
[European Respiratory Journal]
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Efficacy Based Ginger Fingerprinting Reveals Potential Antiproliferative Analytes for Triple Negative Breast Cancer

Researchers characterized the fingerprint profiles of 22 ginger samples using liquid chromatography-mass spectroscopy, followed by a principal component analysis and pearson correlation analysis. They also evaluated the anti-proliferative effects of these samples on TNBC cells using the MTT assays.
[Scientific Reports]
Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer | Scientific Reports. (n.d.). Retrieved November 5, 2020, from https://www.nature.com/articles/s41598-020-75707-0 Cite
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Staphylococcus aureus Second Immunoglobulin-Binding Protein Drives Atopic Dermatitis via IL-33

In vitro human keratinocyte cell culture, ex vivo human skin organ explants and the eczema prone Nc/Tnd mouse were used as model systems to assess type-2 promoting immune responses to S. aureus.
[Journal of Allergy and Clinical Immunology]
Kindi, A. A., Williams, H., Matsuda, K., Alkahtani, A. M., Saville, C., Bennett, H., Alshammari, Y., Tan, S. Y., O’Neill, C., Tanaka, A., Matsuda, H., Arkwright, P. D., & Pennock, J. L. (2020). Staphylococcus aureus Second Immunoglobulin-Binding Protein drives atopic dermatitis via IL-33. Journal of Allergy and Clinical Immunology, 0(0). https://doi.org/10.1016/j.jaci.2020.09.023 Cite
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