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liquid chromatography

Rhoifolin from Plumula Nelumbinis Exhibits Anti-cancer Effects in Pancreatic Cancer via AKT/JNK Signaling Pathways

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

PLA2G6 Silencing Suppresses Melanoma Progression and Affects Ferroptosis Revealed by Quantitative Proteomics

[Frontiers in Oncology] Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes.

Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation

[Journal of Proteome Research] The authors performed an in-depth glycosphingolipid (GSL) glycan analysis of 19 AML cell lines using porous graphitized carbon liquid chromatography-mass spectrometry revealing strikingly different GSL glycan profiles between the various AML cell lines.

Characterizing Human Mesenchymal Stromal Cells’ Immune-Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids

[Cytotherapy] The authors characterized MSCs derived from bone marrow, adipose tissue and umbilical cord tissue for sphingolipids, a class of bioactive lipids, using liquid chromatography/tandem mass spectrometry.

Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs

[Stem Cells] Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.

Comparative Proteome Analysis Identified CD44 as a Possible Serum Marker for Docetaxel Resistance in Castration-Resistant Prostate Cancer

[Journal of Cellular and Molecular Medicine] High serum CD44 levels may help identify docetaxel-resistant patients and may thereby help optimize clinical decision-making regarding type and timing of therapy for metastatic CRPC patients patients.

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