liquid chromatography

[Oncogenesis] The authors mapped the substrates of matrix metalloproteinase 8 (MMP8) to elucidate its previously shown tumor-protective role in oral tongue squamous cell carcinoma. MMP8 overexpressing (+) HSC-3 cells, previously demonstrated to have reduced migration and invasion, showed enhanced cell-cell adhesion.

[Scientific Reports] Researchers assessed the influence of culture duration on the relative proteome abundance of HepG2 cells cultured as spheroids, which are routinely used to model aspects of the liver.

[Scientific Reports] Scientists explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer.

[Scientific Reports] Researchers analyzed the phytoconstituents in ethanolic Ajwa Dates Pulp Extract by liquid chromatography-mass spectrometry and investigated anticancer effects against MDA-MB-231 cells.

[Environmental & Molecular Medicine] Liquid chromatography with tandem mass spectrometry was used to analyze epoxyeicosatrienoic acids (EETs) in the lung tissues of patients with idiopathic pulmonary fibrosis and controls, and the function of 11,12-EET was evaluated in in vitro and in vivo in pulmonary fibrosis models.

[Pediatric Research] Scientists explored differences in metabolites and metabolic pathways between individuals with hyperglycemia or well-controlled gestational diabetes mellitus and healthy controls.