liver cancer

[Scientific Reports] Investigators explored the regulatory mechanism of circFOXM1 in hepatocellular carcinoma (HCC) proliferation and metastasis. RNA polymerase inhibitor actinomycin D and RNase R exonuclease were used to identify circFOXM1 in HCC cells.

[Cell Death Discovery] Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.

[Chem] Researchers prepared CaH2 nanoparticles through liquid-phase exfoliation and first applied them as an antitumor therapeutic agent.

[Scientific Reports] Researchers explored the potential role of integrator complex subunit 8 (INTS8) as a novel diagnostic or therapeutic target in intrahepatic cholangiocarcinoma.

[Cell Death & Disease] Scientists found that inhibition of monocyte-derived macrophages (MoMFs) SYK impaired the expression of CXCL1, reduced the recruitment of inflammatory cells, and promoted the phenotype cross-dress process of pro-resolution MoMFs, thereby remodeling the chronic inflammatory environment of the fibrotic liver.

[Journal of Controlled Release] Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.