Overexpression of Ring Finger Protein 20 Inhibits the Progression of Liver Fibrosis via Mediation of Histone H2B Lysine 120 Ubiquitination

To mimic liver fibrosis in vitro, LX-2 cells were treated with TGF-β. Gene and protein expressions were detected by RT-qPCR and western blot, respectively.
[Human Cell]
Chen, S., Dai, X., Li, H., Gong, Y., Zhao, Y., & Huang, H. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. Human Cell. https://doi.org/10.1007/s13577-021-00498-z Cite
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6His‐Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

In cultured hepatic stellate cells, extracellular 6His‐tagged recombinant human cytoglobin was endocytosed and accumulated in endosomes via clathrin‐mediated pathway.
[Hepatology]
Dat, N. Q., Thuy, L. T. T., Hieu, V. N., Hai, H., Hoang, D. V., Hai, N. T. T., Thuy, T. T. V., Komiya, T., Rombouts, K., Dong, M. P., Hanh, N. V., Hoang, T. H., Sato‐Matsubara, M., Daikoku, A., Kadono, C., Oikawa, D., Yoshizato, K., Tokunaga, F., Pinzani, M., & Kawada, N. (n.d.). 6His-tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31752 Cite
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Dynamically Remodeled Hepatic Extracellular Matrix Predicts Prognosis of Early-Stage Cirrhosis

Investigators systematically analyzed proteomics of decellularized hepatic matrix and identified four unique clusters of ECM proteins at tissue damage/inflammation, transitional ECM remodeling or fibrogenesis stage in carbon tetrachloride-induced liver fibrosis.
[Cell Death & Disease]
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Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer

Scientists showed that PKCδ is a secretory protein that regulated cell growth of liver cancer. Full-length PKCδ was secreted to the extracellular space in living liver cancer cells under normal cell culture conditions and in xenograft mouse models.
[Cancer Research]
Yamada, K., Oikawa, T., Kizawa, R., Motohashi, S., Yoshida, S., Kumamoto, T., Saeki, C., Nakagawa, C., Shimoyama, Y., Aoki, K., Tachibana, T., Saruta, M., Ono, M., & Yoshida, K. (2020). Unconventional secretion of PKCδ exerts tumorigenic function via stimulation of ERK1/2 signaling in liver cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2009 Cite
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MCPIP1 Reduces HBV-RNA by Targeting Its Epsilon Structure

Overexpression of monocyte chemotactic protein-1-induced protein 1 (MCPIP1) decreased hepatitis B virus (HBV) RNA, whereas ablating MCPIP1 in vitro enhanced HBV production. The domains responsible for RNase activity or oligomerization, were required for MCPIP1-mediated viral RNA reduction.
[Scientific Reports]
Li, Y., Que, L., Fukano, K., Koura, M., Kitamura, K., Zheng, X., Kato, T., Aly, H. H., Watashi, K., Tsukuda, S., Aizaki, H., Watanabe, N., Sato, Y., Suzuki, T., Suzuki, H. I., Hosomichi, K., Kurachi, M., Wakae, K., & Muramatsu, M. (2020). MCPIP1 reduces HBV-RNA by targeting its epsilon structure. Scientific Reports, 10(1), 20763. https://doi.org/10.1038/s41598-020-77166-z Cite
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Hepatocellular Carcinoma: Intratumoral EpCAM-Positive Cancer Stem Cell Heterogeneity Identifies High-Risk Tumor Subtype

Scientists investigated the spatial heterogeneity of cancer stem cell-features with the aim of identifying the unique hepatocellular carcinoma patient subgroups amenable to adjuvant treatment.
[BMC Cancer]
Krause, J., von Felden, J., Casar, C., Fründt, T. W., Galaski, J., Schmidt, C., Jung, C., Ittrich, H., Weidemann, S. A., Krech, T., Heumann, A., Li, J., Fischer, L., Sauter, G., Lohse, A. W., Wege, H., & Schulze, K. (2020). Hepatocellular carcinoma: Intratumoral EpCAM-positive cancer stem cell heterogeneity identifies high-risk tumor subtype. BMC Cancer, 20(1), 1130. https://doi.org/10.1186/s12885-020-07580-z Cite
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Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis

Researchers demonstrated that overexpression of Linc‐Pint inhibited the expression of lipogenesis related genes, such as FASN and ACLYM. They also observed that Linc‐Pint significantly inhibits Hepatitis C virus replication.
[Hepatology]
Khatun, M., Sur, S., Steele, R., Ray, R., & Ray, R. B. (n.d.). Inhibition of long noncoding RNA Linc-Pint by hepatitis C virus in infected hepatocytes enhances lipogenesis. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31656 Cite
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Upregulation of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in a Rat Model with Cirrhotic Liver

The expression of C-reactive protein in CCl4-injured rat livers was detected using qRT-PCR and Western blotting after transplantation of placenta-derived MSCs into rats.
[International Journal of Stem Cells]
Jun, J. H., Jung, J., Kim, J. Y., Hwang, S.-G., Bae, S. H., & Kim, G. J. (n.d.). Upregulation of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in A Rat Model with Cirrhotic Liver. International Journal of Stem Cells. https://doi.org/10.15283/ijsc20052 Cite
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Hypoxic Gene Expression in Chronic Hepatitis B Virus Infected Patients Is Not Observed in State-of-the-Art In Vitro and Mouse Infection Models

Scientists used state-of-the-art in vitro and in vivo hepatitis B virus (HBV) infection models to evaluate a role for HBV infection and the viral regulatory protein HBx to drive HIF-signaling.
[Scientific Reports]
Liu, P. J., Harris, J. M., Marchi, E., D’Arienzo, V., Michler, T., Wing, P. A. C., Magri, A., Ortega-Prieto, A. M., van de Klundert, M., Wettengel, J., Durantel, D., Dorner, M., Klenerman, P., Protzer, U., Giotis, E. S., & McKeating, J. A. (2020). Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models. Scientific Reports, 10(1), 14101. https://doi.org/10.1038/s41598-020-70865-7 Cite
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