Transplantation of 3D Adipose-Derived Stem Cell/Hepatocyte Spheroids Alleviates Chronic Hepatic Damage in a Rat Model of Thioacetamide-Induced Liver Cirrhosis

Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.
[Scientific Reports]
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Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
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Soluble CD137 Is a Novel Serum Marker of Liver Cirrhosis in Patients with Hepatitis C and Alcohol-Associated Disease Etiology

Serum soluble CD137 (sCD137) is associated with inflammatory states, and positively correlated with serum tumor necrosis factor in cirrhotic hepatitis C virus (HCV) patients following virus eradication. Researchers argued against a role of sCD137 in HCV infection and suggested a function of sCD137 in liver cirrhosis.
[European Journal of Immunology]
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Mesenchymal Stem Cell Therapy in Decompensated Liver Cirrhosis: A Long-Term Follow-Up Analysis of the Randomized Controlled Clinical Trial

Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.
[Hepatology International]
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EpicentRx Granted New Composition of Matter Patent for Its TGF-ß Trap Fusion Protein

EpicentRx, Inc., a clinical-stage biotechnology company at the forefront of oncolytic viruses and small molecules for the treatment of cancer and other inflammatory-driven diseases, today announced that the United States Patent and Trademark Office (USPTO) has issued U.S. Patent No. 10,906,957 entitled “Immunomodulatory Fusion Proteins.”
[EpicentRx, Inc.]
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Foresight regarding Drug Candidates Acting on the Succinate–GPR91 Signaling Pathway for Non-Alcoholic Steatohepatitis (Nash) Treatment

The authors describe the mechanism of the succinate–GPR91 signaling pathway in NASH and summarize the drugs that act on this pathway, with the aim of providing a new approach to NASH treatment.
[Biomedicine & Pharmacotherapy]
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Matrix Metalloproteinase-9 Inhibition or Deletion Attenuates Portal Hypertension in Rodents

Liver SMAD2 phosphorylation was down-regulated in all series with matrix metalloproteinase (MMP) inhibition or knock-out, and MMP-9 inhibition or deletion ameliorated the severity of cirrhosis, portal hypertension, and associated derangements.
[Journal of Cellular and Molecular Medicine]
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Targeting Epigenetically Maladapted Vascular Niche Alleviates Liver Fibrosis in Nonalcoholic Steatohepatitis

Investigators used multiomics analysis of human cirrhotic liver, a Western diet – and carbon tetrachloride – induced minipig nonalcoholic steatohepatitis model, and genetically modified mice to unravel the landscape of the vascular adaptome at the single-cell level, in which endothelial cells and TH17 cells jointly contributed to liver cirrhosis.
[Science Translational Medicine]
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Poxel Completes Enrollment in Phase II NASH Trial for PXL065 (DESTINY-1) in Biopsy-Proven Patients

POXEL SA announced the completion of enrollment in DESTINY-1, a dose-ranging Phase II trial evaluating PXL065 for the treatment of non-alcoholic steatohepatitis (NASH).
[POXEL SA]
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Conditioned Medium from Stem Cells Derived from Human Exfoliated Deciduous Teeth Ameliorates NASH via the Gut-Liver Axis

The authors examined the benefits of serum-free conditioned medium from stem cells derived from human exfoliated deciduous teeth on a murine non-alcoholic steatohepatitis (NASH) model induced by a combination of Western diet and repeated administration of low doses of carbon tetrachloride intraperitoneally, focusing on the gut-liver axis.
[Scientific Reports]
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Neutrophil Extracellular Traps in Patients with Liver Cirrhosis and Hepatocellular Carcinoma

Plasma markers of neutrophil extracellular traps formation were elevated in liver cirrhosis and correlated to the degree of liver dysfunction in patients with liver cirrhosis and/or hepatocellular carcinoma.
[Scientific Reports]
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