Investigators found hepatic lipocalin 2 (LCN2) expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with alcoholic hepatitis.
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Chen, J., Argemi, J., Odena, G., Xu, M.-J., Cai, Y., Massey, V., Parrish, A., Vadigepalli, R., Altamirano, J., Cabezas, J., Gines, P., Caballeria, J., Snider, N., Sancho-Bru, P., Akira, S., Rusyn, I., Gao, B., & Bataller, R. (2020). Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension. Scientific Reports, 10(1), 15558. https://doi.org/10.1038/s41598-020-72172-7 Cite
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Researchers elucidated the anti-fibrotic effects of neratinib in hepatic stellate cells (HSCs) and in vivo models of CCl4-induced liver fibrosis. HSC activation was a key step in liver fibrogenesis and played a crucial role in collagen deposition, as it is primarily responsible for excessive ECM production.
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Park, Y. J., An, H.-T., Park, J.-S., Park, O., Duh, A. J., Kim, K., Chung, K. H., Lee, K. C., Oh, Y., & Lee, S. (2020). Tyrosine kinase inhibitor neratinib attenuates liver fibrosis by targeting activated hepatic stellate cells. Scientific Reports, 10(1), 14756. https://doi.org/10.1038/s41598-020-71688-2 Cite
Scientists investigated the effect of human fetal skin-derived stem cell (hFSSC) secretome in the treatment of liver fibrosis. They investigated the anti-fibrotic mechanism of hFSSC secretome in hepatic stellate cells.
[Stem Cell Research & Therapy]
This review explores the causes and mechanisms of hepatic fibrosis and focuses on the roles of key molecules involved in liver fibro genesis, some of which are potential targets for therapeutics to hamper liver fibro genesis.
[Journal of Interferon and Cytokine Research]
To investigate the effect of ECM stiffness on hepatocyte migration and function, scientists designed an easy fabricated polyvinyl alcohol hydrogel in which stiffness could be controlled by changing the concentration of glutaraldehyde.
The authors aimed to investigate the restorative effects of mouse bone marrow mesenchymal stem cells (mBMSCs) on thioacetamide‐induced damage in hepatocytes. An in vitro trans‐well co‐culture system of HepG2 cells were co‐cultured with mBMSCs.
[Cell Biology International]
Scientists investigated the effect of leptin on the expression of Mat2b in hepatic stellate cells in vitro and in a leptin‐deficient mouse model. Results demonstrated that leptin significantly increased Mat2b expression.
[Journal of Pathology]
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Wild‐type, KitW‐sh, and Mdr2‐/‐ mice lacking l‐histidine decarboxylase were injected with vehicle or PKH26‐tagged murine mast cells pretreated with 0.01% DMSO or the TGF‐βR inhibitor,
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Induced hepatocyte-like (iHep) cells were generated from induced pluripotent stem cells integrated with the albumin reporter gene. The therapeutic properties of these iHep cells were investigated after transplantation in fibrotic liver tissues of a mouse model.
[Stem Cell Research & Therapy]
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Fibrosis, or the accumulation of ECM, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, scientists cross-examined human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models.
[Cell Reports Medicine]
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Zhang, J., Muise, E. S., Han, S., Kutchukian, P. S., Costet, P., Zhu, Y., Kan, Y., Zhou, H., Shah, V., Huang, Y., Saigal, A., Akiyama, T. E., Shen, X.-L., Cai, T.-Q., Shah, K., Carballo-Jane, E., Zycband, E., Yi, L., Tian, Y., … Pinto, S. (2020). Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis. Cell Reports Medicine, 1(4). https://doi.org/10.1016/j.xcrm.2020.100056 Cite