liver fibrosis

[Cellular & Molecular Immunology] Agonist-induced stimulator of interferon genes (STING) signaling activation in macrophages was revealed to inhibit covalently closed circular DNA-mediated transcription and hepatitis B virus (HBV) replication via epigenetic modification in hepatocytes.

[Journal of Hepatology] Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.

[Life Sciences] Researchers investigated the role of survivin protein in early fibrogenic activation of hepatic stellate cells and fibrosis progression in chronic liver injury.

[Scientific Reports] Investigators found that miR-571 inhibited the apoptosis of human hepatic stellate cells and promoted cell proliferation and migration. Its up regulation promoted the expression of Notch3 and Jagged1, and promoted the expression of related fibroblasts.

[International Journal of Stem Cells] Investigators introduced a rat model of liver fibrosis and trans-portal transplantation of human liver stem cells to demonstrate alleviation of liver fibrosis.

[Journal of Gastroenterology and Hepatology] The autophagy attenuation exerted by chloroquine together with the reduction of the expression of the proliferation marker in hepatic stellate cells could lessen the acute liver damage, potentially opening the way to novel therapeutic approaches for hepatic fibrosis.