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lung cancer cells

Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

[Frontiers in Cell and Developmental Biology] Scientists found that halofuginone inhibited the proliferation, induced G0/G1 phase arrest, and promoted apoptosis in lung cancer cells in a dose-dependent manner.

Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development

[Cold Spring Harbor Perspectives in Medicine] Work in model systems has provided insights into the biology of lung cancer subtypes and their origins, contributed to our understanding of the mechanisms that underlie tumor progression, and revealed new therapeutic vulnerabilities.

Ad-Apoptin Inhibits Glycolysis, Migration and Invasion in Lung Cancer Cells Targeting AMPK/mTOR Signaling Pathway

[Experimental Cell Research] Researchers investigated the effects of Ad-apoptin on glycolysis, migration and invasion of non-small cell lung cancer.

TGF-β-Mediated Epithelial–Mesenchymal Transition and Tumor-Promoting Effects in CMT64 Cells Are Reflected in the Transcriptomic Signature of Human Lung Adenocarcinoma

[Scientific Reports] Scientists demonstrated for the first time that TGF-β could elicit epithelial–mesenchymal transition in a mouse lung adenocarcinoma cell line.

Nuclear Accumulation of KPNA2 Impacts Radioresistance through Positive Regulation of the PLSCR1-STAT1 Loop in Lung Adenocarcinoma

[Cancer Science] Researchers demonstrated that high expression of karyopherin α2 was positively correlated with radioresistance and CSC properties in lung adenocarcinoma cells.

Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 1 Increases Cellular Proliferation and Colony Formation Capacity in Lung Cancer via Activation of E2F Transcription Factor 1

[Oncology Letters] High PLOD1 mRNA levels have been determined to be prognostically significant in numerous human malignancies. Researchers elucidated the pathological mechanism of procollagen‑lysine, 2‑oxoglutarate 5‑dioxygenase 1 in lung cancer.

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