The Lung Cancer Research Foundation announced a collaboration with AstraZeneca to fund over $900,000 in research grants focused on understanding resistance to epidermal growth factor receptor tyrosine kinase inhibitors and immune checkpoint inhibitors, including therapeutic approaches to overcome these mechanisms, as well as biomarkers of immune-mediated adverse events.
[Lung Cancer Research Foundation]
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Researchers investigated the expression of ZNF674-AS1 in 83 pairs of NSCLC specimens and adjacent noncancerous lung tissues. The clinical significance of ZNF674-AS1 in NSCLC was analyzed. The role of ZNF674-AS1 in NSCLC growth and cell cycle progression was explored.
[Cellular & Molecular Biology Letters]
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The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
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Scientists evaluated the impact of down-regulation of LINK-A in A549 and Calu-3 cell lines as cellular models of NSCLC.
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RT‐qPCR was used to measure the expression of genes. Actinomycin D and RNase R were employed to examine the stability of circVAPA. CCK‐8, EdU, Transwell, sphere formation assay, and western blot analysis were conducted to examine the changes of NSCLC cells in response to circVAPA knockdown. Luciferase reporter assay was conducted for molecular mechanism.
[Journal of Gene Medicine]
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Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.
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Scientists observed that chronic intermittent hypoxia endowed lung cancer with greater metastatic potential, evidenced by increased tumor growth, tumor seeding, and upregulated cancer stem cells-related gene expression in the lungs.
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The authors investigated the function of the cancer stem cell marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
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MacDonagh, L., Santiago, R. M., Gray, S. G., Breen, E., Cuffe, S., Finn, S. P., O’Byrne, K. J., & Barr, M. P. (2021). Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin. Translational Oncology, 14(4), 101025. https://doi.org/10.1016/j.tranon.2021.101025 Cite
Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]
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Shu, X., Cao, K.-Y., Liu, H.-Q., Yu, L., Sun, L.-X., Yang, Z.-H., Wu, C.-A., & Ran, Y.-L. (2021). Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway. Stem Cell Research & Therapy, 12(1), 119. https://doi.org/10.1186/s13287-021-02160-9 Cite
The potential role of miR-146a as a diagnostic marker of lung cancer must be analyzed. Scientists summarize the tumor-suppressing, anti-inflammatory, and antichemoresistive nature of miR-146a in lung cancer.
The author touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.
[Nature Reviews Cancer]