EGFR-ERK Induced Activation of GRHL1 Promotes Cell Cycle Progression by Up-Regulating Cell Cycle Related Genes in Lung Cancer

Scientists found that GRHL1 was upregulated in non-small cell lung cancer and correlated with poor survival of patients.
[Cell Death & Disease]
He, Y., Gan, M., Wang, Y., Huang, T., Wang, J., Han, T., & Yu, B. (2021). EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer. Cell Death & Disease, 12(5), 1–13. https://doi.org/10.1038/s41419-021-03721-9 Cite
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Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-small Cell Lung Cancer

Researchers investigated the acquired resistance mechanism of epidermal growth factor receptor kinase domain duplication (EGFR-KDD) against EGFR-tyrosine kinase inhibitors (EGFR TKIs).
[Cancer Research and Treatment]
Lee, C., Kim, M., Kim, D.-W., Kim, T. M., Kim, S., Im, S.-W., Jeon, Y. K., Keam, B., Ku, J.-L., & Heo, D. S. (2021). Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer. Cancer Research and Treatment. https://doi.org/.0.0.0 Cite
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Single-Cell Profiling of Tumor Heterogeneity and the Microenvironment in Advanced Non-small Cell Lung Cancer

we analyze 42 tissue biopsy samples from stage III/IV non-small cell lung cancer (NSCLC) patients by single cell RNA sequencing and present the large scale, single cell resolution profiles of advanced NSCLCs.
[Nature Communications]
Wu, F., Fan, J., He, Y., Xiong, A., Yu, J., Li, Y., Zhang, Y., Zhao, W., Zhou, F., Li, W., Zhang, J., Zhang, X., Qiao, M., Gao, G., Chen, S., Chen, X., Li, X., Hou, L., Wu, C., … Zhou, C. (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nature Communications, 12(1), 2540. https://doi.org/10.1038/s41467-021-22801-0 Cite
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Regulation of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.
[Scientific Reports]
Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J., Heyl, D., & Evans, H. G. (2021). Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific Reports, 11(1), 9708. https://doi.org/10.1038/s41598-021-88574-0 Cite
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Nanoparticle-Mediated Tumor Cell Expression of mIL-12 via Systemic Gene Delivery Treats Syngeneic Models of Murine Lung Cancers

We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under the control of the cancer-selective progression elevated gene 3 (PEG-3) promoter, to treat tumors in the lungs of diseased mice.
[Scientific Reports]
Ahn, H.-H., Carrington, C., Hu, Y., Liu, H., Ng, C., Nam, H., Park, A., Stace, C., West, W., Mao, H.-Q., Pomper, M. G., Ullman, C. G., & Minn, I. (2021). Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers. Scientific Reports, 11(1), 9733. https://doi.org/10.1038/s41598-021-89124-4 Cite
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Is There a Role for Percutaneous Ablation for Early Stage Lung Cancer? What Is the Evidence?

we review data published with different thermal ablation (TA) techniques: radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation. This paper reviews also the comparison that has been made between TA and stereotactic radiotherapy (SBRT).
[Current Oncology Reports]
Palussière, J., Cazayus, M., Cousin, S., Cabart, M., Chomy, F., Catena, V., & Buy, X. (2021). Is There a Role for Percutaneous Ablation for Early Stage Lung Cancer? What Is the Evidence? Current Oncology Reports, 23(7), 81. https://doi.org/10.1007/s11912-021-01072-4 Cite
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Genprex Initiates Site Recruitment for Acclaim-2 Clinical Trial for the Treatment of Non-Small Cell Lung Cancer

Genprex, Inc. announced it has commenced clinical trial site recruitment for its upcoming Acclaim-2 clinical trial for the treatment of non-small cell lung cancer.
[Genprex, Inc. (BusinessWire, Inc.)]
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Triptolide Suppresses the Growth and Metastasis of Non-small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition

Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]
Deng, Q., Lei, X., Zhong, Y., Chen, M., Ke, Y., Li, Z., Chen, J., Huang, L., Zhang, Y., Liang, L., Lin, Z., Liu, Q., Li, S., & Yu, X. (2021). Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00657-w Cite
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m6A Demethylase FTO Induces NELL2 Expression by Inhibiting E2F1 m6A Modification Leading to Metastasis of Non-Small-Cell Lung Cancer

Scientists explored the regulatory role of E2F transcription factor-1 and underlying mechanism in non-small-cell lung cancer development.
[Molecular Therapy-Oncolytics]
Wang, Y., Li, M., Zhang, L., Chen, Y., & Zhang, S. (2021). m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small-cell lung cancer. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.04.011 Cite
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ALK Inhibition Activates LC3B-Independent, Protective Autophagy in EML4-ALK Positive Lung Cancer Cells

Investigators asked whether ALK inhibition affected autophagy, and whether this might influence treatment response.
[Scientific Reports]
Schläfli, A. M., Tokarchuk, I., Parejo, S., Jutzi, S., Berezowska, S., Engedal, N., & Tschan, M. P. (2021). ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells. Scientific Reports, 11(1), 9011. https://doi.org/10.1038/s41598-021-87966-6 Cite
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Schisandrin B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling Pathways

established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that Schisandrin B inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.
[Oncology Reports]
Li, S., Wang, H., Ma, R., & Wang, L. (2021). Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways. Oncology Reports, 45(6), 1–13. https://doi.org/10.3892/or.2021.8066 Cite
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