LCRF Announces New Research Collaboration with AstraZeneca

The Lung Cancer Research Foundation announced a collaboration with AstraZeneca to fund over $900,000 in research grants focused on understanding resistance to epidermal growth factor receptor tyrosine kinase inhibitors and immune checkpoint inhibitors, including therapeutic approaches to overcome these mechanisms, as well as biomarkers of immune-mediated adverse events.
[Lung Cancer Research Foundation]
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ZNF674-AS1 Antagonizes miR-423-3p to Induce G0/G1 Cell Cycle Arrest in Non-small Cell Lung Cancer Cells

Researchers investigated the expression of ZNF674-AS1 in 83 pairs of NSCLC specimens and adjacent noncancerous lung tissues. The clinical significance of ZNF674-AS1 in NSCLC was analyzed. The role of ZNF674-AS1 in NSCLC growth and cell cycle progression was explored.
[Cellular & Molecular Biology Letters]
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Pentraxin 3 Acts as a Functional Effector of Akt/NF-κB Signaling to Modulate the Progression and Cisplatin-Resistance in Non-Small Cell Lung Cancer

The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
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The Role of Long Intergenic Non-Coding RNA for Kinase Activation (LINK-A) as an Oncogene in Non-Small Cell Lung Carcinoma

Scientists evaluated the impact of down-regulation of LINK-A in A549 and Calu-3 cell lines as cellular models of NSCLC.
[Scientific Reports]
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CircVAPA Exerts Oncogenic Property in Non‐Small Cell Lung Cancer by the miR‐876‐5p/WNT5A Axis

RT‐qPCR was used to measure the expression of genes. Actinomycin D and RNase R were employed to examine the stability of circVAPA. CCK‐8, EdU, Transwell, sphere formation assay, and western blot analysis were conducted to examine the changes of NSCLC cells in response to circVAPA knockdown. Luciferase reporter assay was conducted for molecular mechanism.
[Journal of Gene Medicine]
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Neuron Specific Enolase Promotes Tumor Metastasis by Activating the Wnt/β-Catenin Pathway in Small Cell Lung Cancer

Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.
[Translational Oncology]
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Chronic Intermittent Hypoxia Promoted Lung Cancer Stem Cell-Like Properties via Enhancing Bach1 Expression

Scientists observed that chronic intermittent hypoxia endowed lung cancer with greater metastatic potential, evidenced by increased tumor growth, tumor seeding, and upregulated cancer stem cells-related gene expression in the lungs.
[Respiratory Research]
Hao, S., Zhu, X., Liu, Z., Wu, X., Li, S., Jiang, P., & Jiang, L. (2021). Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression. Respiratory Research, 22(1), 58. https://doi.org/10.1186/s12931-021-01655-6 Cite
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Exploitation of the Vitamin A/Retinoic Acid Axis Depletes ALDH1-Positive Cancer Stem Cells and Re-Sensitizes Resistant Non-Small Cell Lung Cancer Cells to Cisplatin

The authors investigated the function of the cancer stem cell marker aldehyde dehydrogenase in retinoic acid cell signaling using an in vitro model of cisplatin resistant non-small cell lung cancer.
[Translational Oncology]
MacDonagh, L., Santiago, R. M., Gray, S. G., Breen, E., Cuffe, S., Finn, S. P., O’Byrne, K. J., & Barr, M. P. (2021). Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin. Translational Oncology, 14(4), 101025. https://doi.org/10.1016/j.tranon.2021.101025 Cite
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Alpha-Enolase (ENO1), Identified as an Antigen to Monoclonal Antibody 12C7, Promotes the Self-Renewal and Malignant Phenotype of Lung Cancer Stem Cells by AMPK/mTOR Pathway

Immunofluorescence was used for antigen localization. After targeted antigen purification by electrophoresis and immunoblot, the antigen was identified by LC-MALDI-TOF/TOF mass spectrometry, immunofluorescence, and immunoprecipitation.
[Stem Cell Research & Therapy]
Shu, X., Cao, K.-Y., Liu, H.-Q., Yu, L., Sun, L.-X., Yang, Z.-H., Wu, C.-A., & Ran, Y.-L. (2021). Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway. Stem Cell Research & Therapy, 12(1), 119. https://doi.org/10.1186/s13287-021-02160-9 Cite
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Clinico-Pathological Importance of miR-146a in Lung Cancer

The potential role of miR-146a as a diagnostic marker of lung cancer must be analyzed. Scientists summarize the tumor-suppressing, anti-inflammatory, and antichemoresistive nature of miR-146a in lung cancer.
[Diagnostics]
Diagnostics | Free Full-Text | Clinico-Pathological Importance of miR-146a in Lung Cancer. (n.d.). Retrieved February 17, 2021, from https://www.mdpi.com/2075-4418/11/2/274 Cite
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The Matrix in Cancer

The author touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.
[Nature Reviews Cancer]
Cox, T. R. (2021). The matrix in cancer. Nature Reviews Cancer, 1–22. https://doi.org/10.1038/s41568-020-00329-7 Cite
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