Scientists found that GRHL1 was upregulated in non-small cell lung cancer and correlated with poor survival of patients.
[Cell Death & Disease]
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Researchers investigated the acquired resistance mechanism of epidermal growth factor receptor kinase domain duplication (EGFR-KDD) against EGFR-tyrosine kinase inhibitors (EGFR TKIs).
[Cancer Research and Treatment]
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we analyze 42 tissue biopsy samples from stage III/IV non-small cell lung cancer (NSCLC) patients by single cell RNA sequencing and present the large scale, single cell resolution profiles of advanced NSCLCs.
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Wu, F., Fan, J., He, Y., Xiong, A., Yu, J., Li, Y., Zhang, Y., Zhao, W., Zhou, F., Li, W., Zhang, J., Zhang, X., Qiao, M., Gao, G., Chen, S., Chen, X., Li, X., Hou, L., Wu, C., … Zhou, C. (2021). Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nature Communications, 12(1), 2540. https://doi.org/10.1038/s41467-021-22801-0 Cite
identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.
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Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J., Heyl, D., & Evans, H. G. (2021). Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific Reports, 11(1), 9708. https://doi.org/10.1038/s41598-021-88574-0 Cite
We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under the control of the cancer-selective progression elevated gene 3 (PEG-3) promoter, to treat tumors in the lungs of diseased mice.
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Ahn, H.-H., Carrington, C., Hu, Y., Liu, H., Ng, C., Nam, H., Park, A., Stace, C., West, W., Mao, H.-Q., Pomper, M. G., Ullman, C. G., & Minn, I. (2021). Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers. Scientific Reports, 11(1), 9733. https://doi.org/10.1038/s41598-021-89124-4 Cite
we review data published with different thermal ablation (TA) techniques: radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation. This paper reviews also the comparison that has been made between TA and stereotactic radiotherapy (SBRT).
[Current Oncology Reports]
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Genprex, Inc. announced it has commenced clinical trial site recruitment for its upcoming Acclaim-2 clinical trial for the treatment of non-small cell lung cancer.
[Genprex, Inc. (BusinessWire, Inc.)]
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Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]
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Deng, Q., Lei, X., Zhong, Y., Chen, M., Ke, Y., Li, Z., Chen, J., Huang, L., Zhang, Y., Liang, L., Lin, Z., Liu, Q., Li, S., & Yu, X. (2021). Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00657-w Cite
Scientists explored the regulatory role of E2F transcription factor-1 and underlying mechanism in non-small-cell lung cancer development.
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Investigators asked whether ALK inhibition affected autophagy, and whether this might influence treatment response.
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established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that Schisandrin B inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.
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Li, S., Wang, H., Ma, R., & Wang, L. (2021). Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways. Oncology Reports, 45(6), 1–13. https://doi.org/10.3892/or.2021.8066 Cite