Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer

Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
[Oncogene]
Full Article

Continue reading “Impaired AKT Signaling and Lung Tumorigenesis by PIERCE1 Ablation in KRAS-Mutant Non-Small Cell Lung Cancer”

Bookmark

No account yet? Register

0
Share

Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
Abstract

Continue reading “Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells”

Bookmark

No account yet? Register

0
Share

Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Cheng, J., Lin, M., Chu, M., Gong, L., Bi, Y., & Zhao, Y. (2020). Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-00303-0 Cite
Full Article

Continue reading “Emerging Role of FBXO22 in Carcinogenesis”

Bookmark

No account yet? Register

0
Share

Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Full Article

Continue reading “Emerging Role of FBXO22 in Carcinogenesis”

Bookmark

No account yet? Register

0
Share

Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
[iScience]
AbstractGraphical Abstract

Continue reading “Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening”

Bookmark

No account yet? Register

0
Share

CircSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer by Targeting miR-520h/ABCG2 Pathway

The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
[Molecular Therapy-Nucleic Acids]
AbstractGraphical Abstract

Continue reading “CircSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer by Targeting miR-520h/ABCG2 Pathway”

Bookmark

No account yet? Register

0
Share

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
[Cancer Cell]
AbstractGraphical Abstract

Continue reading “Emergence of a High-Plasticity Cell State during Lung Cancer Evolution”

Bookmark

No account yet? Register

0
Share

NRF2-GPX4/SOD2 Axis Imparts Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cells

The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
[Acta Pharmacologica Sinica]
Abstract

Continue reading “NRF2-GPX4/SOD2 Axis Imparts Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cells”

Bookmark

No account yet? Register

0
Share

Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
[Cancer Research]
Abstract

Continue reading “Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma”

Bookmark

No account yet? Register

0
Share

TRIB3-EGFR Interaction Promotes Lung Cancer Progression and Defines a Therapeutic Target

Researchers report that the elevated tribbles pseudokinase 3 (TRIB3) was positively associated with epidermal growth factor receptor (EGFR) stability and non-small cell lung cancer progression.
[Nature Communications]
Full Article

Continue reading “TRIB3-EGFR Interaction Promotes Lung Cancer Progression and Defines a Therapeutic Target”

Bookmark

No account yet? Register

0
Share

A Novel TRPM7/O-GlcNAc Axis Mediates Tumor Cell Motility and Metastasis by Stabilising c-Myc and Caveolin-1 in Lung Carcinoma

Inhibition of TRPM7 suppressed cell motility in various non-small cell lung cancer cell lines and patient-derived primary cells and attenuated experimental lung metastases.
[British Journal of Cancer]
Luanpitpong, S., Rodboon, N., Samart, P., Vinayanuwattikun, C., Klamkhlai, S., Chanvorachote, P., Rojanasakul, Y., & Issaragrisil, S. (2020). A novel TRPM7/ O -GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0991-7 Cite
Full Article

Continue reading “A Novel TRPM7/O-GlcNAc Axis Mediates Tumor Cell Motility and Metastasis by Stabilising c-Myc and Caveolin-1 in Lung Carcinoma”

Bookmark

No account yet? Register

0
Share

Discovery of New Fluorescent Thiazole–Pyrazoline Derivatives as Autophagy Inducers by Inhibiting mTOR Activity in A549 Human Lung Cancer Cells

A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo.
[Cell Death & Disease]
Full Article

Continue reading “Discovery of New Fluorescent Thiazole–Pyrazoline Derivatives as Autophagy Inducers by Inhibiting mTOR Activity in A549 Human Lung Cancer Cells”

Bookmark

No account yet? Register

0
Share
Share