Investigators showed the tumor-promoting function of a cell cycle-related protein, PIERCE1, in KRAS-mutant non-small cell lung cancer. Mechanistically, PIERCE1 depletion inhibited cell growth and AKT phosphorylation at S473, which was particularly observed in KRAS-mutant lung cancers.
1254621 Z3BFTNKQ items 1 apa default asc 1
The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
1254621 W4GAXKJA items 1 apa default asc 1
Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
1254621 YK2FQKWE items 1 apa default asc 1
Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
1254621 VA8XQQLM items 1 apa default asc 1
The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
[Molecular Therapy-Nucleic Acids]
1254621 59SZ2B9G items 1 apa default asc 1
The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
1254621 ICFFXRMS items 1 apa default asc 1
The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
[Acta Pharmacologica Sinica]
1254621 NBEGL9TG items 1 apa default asc 1
Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
1254621 PGW6HIVH items 1 apa default asc 1
Researchers report that the elevated tribbles pseudokinase 3 (TRIB3) was positively associated with epidermal growth factor receptor (EGFR) stability and non-small cell lung cancer progression.
1254621 ZXUUEAHM items 1 apa default asc 1
Inhibition of TRPM7 suppressed cell motility in various non-small cell lung cancer cell lines and patient-derived primary cells and attenuated experimental lung metastases.
[British Journal of Cancer]
1254621 UUN9CN5W items 1 apa default asc 1
Luanpitpong, S., Rodboon, N., Samart, P., Vinayanuwattikun, C., Klamkhlai, S., Chanvorachote, P., Rojanasakul, Y., & Issaragrisil, S. (2020). A novel TRPM7/ O -GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0991-7 Cite
A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo.
[Cell Death & Disease]
1254621 5MT6PK2D items 1 apa default asc 1