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lung cancer

TGF-β-Dependent Reprogramming of Amino Acid Metabolism Induces Epithelial–Mesenchymal Transition in Non-small Cell Lung Cancers

[Communications Biology] Investigators showed that TGF-β induced reprogramming of intracellular amino acid metabolism, which was necessary to promote epithelial–mesenchymal transition in non-small cell lung cancer cells.

Selecting the Optimal Immunotherapy Regimen in Driver-Negative Metastatic NSCLC

[Nature Reviews Clinical Oncology] The authors discuss the current treatment landscape and detail their approach to first-line immunotherapy regimen selection for patients with advanced-stage, driver-negative NSCLC.

Targeting Therapy-Resistant Lung Cancer Stem Cells via Disruption of the AKT/TSPYL5/PTEN Positive-Feedback Loop

[Communications Biology] Researchers identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells, and suggested this as a therapeutic target for CSC elimination.

Ionizing Radiation Curtails Immunosuppressive Effects from Cancer-Associated Fibroblasts on Dendritic Cells

[Frontiers in Immunology] Scientists investigated the effects of ionizing radiation on cancer-associated fibroblast (CAF)-mediated regulation of dendritic cells (DCs). CAFs were obtained from freshly operated lung cancer tissues, while DCs were procured from peripheral blood of healthy donors.

Cancer-Specific Immune Evasion and Substantial Heterogeneity within Cancer Types Provide Evidence for Personalized Immunotherapy

[npj Precision Oncology] Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.

Targeting Regulator of G Protein Signaling 1 in Tumor-Specific T Cells Enhances Their Trafficking to Breast Cancer

[Nature Immunology] Scientists found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking to and survival in tumors and was associated with shorter survival of patients with breast and lung cancer.

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