Tag results:
lung cancer
Pulmonary Cell News
TGF-β-Dependent Reprogramming of Amino Acid Metabolism Induces Epithelial–Mesenchymal Transition in Non-small Cell Lung Cancers
[Communications Biology] Investigators showed that TGF-β induced reprogramming of intracellular amino acid metabolism, which was necessary to promote epithelial–mesenchymal transition in non-small cell lung cancer cells.
Pulmonary Cell News
Selecting the Optimal Immunotherapy Regimen in Driver-Negative Metastatic NSCLC
[Nature Reviews Clinical Oncology] The authors discuss the current treatment landscape and detail their approach to first-line immunotherapy regimen selection for patients with advanced-stage, driver-negative NSCLC.
Cancer Stem Cell News
Targeting Therapy-Resistant Lung Cancer Stem Cells via Disruption of the AKT/TSPYL5/PTEN Positive-Feedback Loop
[Communications Biology] Researchers identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells, and suggested this as a therapeutic target for CSC elimination.
Human Immunology News
Ionizing Radiation Curtails Immunosuppressive Effects from Cancer-Associated Fibroblasts on Dendritic Cells
[Frontiers in Immunology] Scientists investigated the effects of ionizing radiation on cancer-associated fibroblast (CAF)-mediated regulation of dendritic cells (DCs). CAFs were obtained from freshly operated lung cancer tissues, while DCs were procured from peripheral blood of healthy donors.
Cell Therapy News
Cancer-Specific Immune Evasion and Substantial Heterogeneity within Cancer Types Provide Evidence for Personalized Immunotherapy
[npj Precision Oncology] Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.
Human Immunology News
Targeting Regulator of G Protein Signaling 1 in Tumor-Specific T Cells Enhances Their Trafficking to Breast Cancer
[Nature Immunology] Scientists found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking to and survival in tumors and was associated with shorter survival of patients with breast and lung cancer.