lung cancer

[NPJ Genomic Medicine] Scientists presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.

[Cells] The authors critically analyse the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.

[Turning Point Therapeutics, Inc.] Turning Point Therapeutics, Inc. announced that TPX-0022, the company’s inhibitor of MET and the associated cancer signaling pathways of SRC and CSF1R, has been granted orphan drug designation by the Food and Drug Administration (FDA) for the treatment of patients with gastric cancer, including gastroesophageal junction adenocarcinoma.

[Nature] Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.

[npj Genomic Medicine] Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. The authors presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.

[Immunology] Scientists performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer patients and found that epigenetic downregulation of B2M was common.