lung carcinoma

[Cell Death Discovery] The authors found that SH3PXD2A-AS1 expression in NSCLC tissues was upregulated compared with that in normal lung tissues in The Cancer Genome Atlas database by using the GEPIA website.

[Cancer Immunology Immunotherapy] In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate programmed cell death-1 ligand 1 expression on macrophages via STAT3 activation.

[Gene Therapy] The authors reported how nuclear factor erythroid 2-related factor 2 disruption led to collateral damage in the form of CRISPR-mediated exon skipping.

[Immunity] Although PD-1 and TIGIT are thought to regulate different costimulatory receptors, effectiveness of PD-1 or TIGIT inhibition in preclinical tumor models was reduced in the absence of CD226.

[Nature Cancer] Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.

[Molecular Cancer Research] Pharmacologic inhibition of mTOR kinase by Torin2 significantly sensitized lung squamous cell carcinoma cell lines to ionizing radiation.