Integrated Transcription Factor Profiling with Transcriptome Analysis Identifies L1PA2 Transposons as Global Regulatory Modulators in a Breast Cancer Model

The authors applied the pipeline to a breast cancer model, and found that the L1PA2 transposon subfamily contributes abundant regulatory sequences to co-ordinated transcriptional regulation in breast cancer.
[Scientific Reports]
Jiang, J.-C., Rothnagel, J. A., & Upton, K. R. (2021). Integrated transcription factor profiling with transcriptome analysis identifies L1PA2 transposons as global regulatory modulators in a breast cancer model. Scientific Reports, 11(1), 8083. https://doi.org/10.1038/s41598-021-86395-9 Cite
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Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain

Researchers report that depletion of sciatic nerve resident macrophages (rMΦ) in mice attenuated mechanical/cold hypersensitivity and spontaneous pain evoked by intraplantar injection of melanoma or lung carcinoma cells. Targeted deletion of transient receptor potential ankyrin 1 (Trpa1) revealed a key role for Schwann cell TRPA1 in sciatic nerve rMΦ expansion and pain-like behaviors.
[Cancer Research]
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Synergistic Effects of Type I PRMT and PARP Inhibitors against Non-Small Cell Lung Cancer Cells

The combination of MS023, a type I protein arginine methyltransferases (PRMT) inhibitor, and the PARP inhibitor BMN-673 demonstrated strong synergistic interaction at low nanomolar concentrations in methylthioadenosine phosphorylase-negative NSCLC cell lines A549, SK-LU-1 and HCC4006.
[Clinical Epigenetics]
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The Role of Long Intergenic Non-Coding RNA for Kinase Activation (LINK-A) as an Oncogene in Non-Small Cell Lung Carcinoma

Scientists evaluated the impact of down-regulation of LINK-A in A549 and Calu-3 cell lines as cellular models of NSCLC.
[Scientific Reports]
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Genomic Profiles and Tumor Immune Microenvironment of Primary Lung Carcinoma and Brain Oligo-Metastasis

Scientists recruited 33 lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor immune microenvironment of the lung and brain metastasis independently.
[Cell Death & Disease]
Song, Z., Yang, L., Zhou, Z., Li, P., Wang, W., Cheng, G., Chen, R., Chang, L., Zhang, Y., Guan, Y., Xia, X., Yi, X., Zhou, R., & Chen, M. (2021). Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis. Cell Death & Disease, 12(1), 1–10. https://doi.org/10.1038/s41419-021-03410-7 Cite
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Inhibition of Tumor Invasion and Metastasis by Targeting TGF-β-Smad-MMP2 Pathway with Asiatic Acid and Naringenin

Scientists found that combined therapy with Asiatic Acid, a Smad7 agonist, and Naringenin, a Smad3 inhibitor, effectively retrieved the balance between Smad3 and Smad7 signaling in the TGF-β-rich tumor microenvironment and thus significantly suppressed tumor invasion and metastasis in mouse models of melanoma and lung carcinoma.
[Molecular Therapy-Oncolytics]
Lian, G.-Y., Wang, Q.-M., Mak, T. S.-K., Huang, X.-R., Yu, X.-Q., & Lan, H.-Y. (2021). Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.01.006 Cite
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Cyclophilin A Inhibits A549 Cell Oxidative Stress and Apoptosis by Modulating the PI3K/Akt/mTOR Signaling Pathway

Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
[Bioscience Reports]
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Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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DRAM1 Plays a Tumor Suppressor Role in NSCLC Cells by Promoting Lysosomal Degradation of EGFR

Scientists confirmed that DNA damage-regulated autophagy modulator 1 (DRAM1) inhibited the growth, migration, and invasion of nonsmall-cell lung carcinoma cells in vitro.
[Cell Death & Disease]
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In Vitro: Cytotoxicity, Apoptosis and Ameliorative Potential of Lawsonia inermis extract in Human Lung, Colon and Liver Cancer Cell Lines

Bioactive components of Lawsonia inermis extract were analyzed by the LCMS/MS method and validated. Lawsone (3.5%), is primarily responsible for cytotoxic and anti-cancerous activities. These properties were studied on human lung carcinoma, colorectal cancer and hepatocellular carcinoma cancer cell lines.
[Cancer Investigation]
Ishteyaque, S., Mishra, A., Mohapatra, S., Singh, A., Bhatta, R. S., Narender, T., & Mugale, M. N. (2020). In Vitro: Cytotoxicity, Apoptosis and Ameliorative Potential of Lawsonia inermis extract in Human Lung, Colon and Liver Cancer Cell line. Cancer Investigation, 0(ja), 1–13. https://doi.org/10.1080/07357907.2020.1811300 Cite
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miR-21a in Exosomes from Lewis Lung Carcinoma Cells Accelerates Tumor Growth through Targeting PDCD4 to Enhance Expansion of Myeloid-Derived Suppressor Cells

Researchers demonstrated that LLC-Exo accelerated tumor growth along with a significant accumulation of MDSCs in mouse tumor model.
[Oncogene]
Zhang, X., Li, F., Tang, Y., Ren, Q., Xiao, B., Wan, Y., & Jiang, S. (2020). miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01406-9 Cite
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