lupus

[Nature Biomedical Engineering] The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.

[Acta Pharmacologica Sinica] Researchers investigated whether norcantharidin (NCTD) exerted therapeutic effects in a mouse systemic lupus erythematosu model. Lupus prone female MRL/lpr mice were treated with NCTD for eight weeks.

[Nature Immunology] The authors showed that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus undergo ferroptosis.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the mechanism of how SLC15A4 directed inflammatory responses. Proximity-dependent biotin identification revealed glycolysis as highly enriched gene ontology terms.

[Scientific Reports] To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.

[Nature Communications] Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.