Melanoma-Derived Small Extracellular Vesicles Induce Lymphangiogenesis and Metastasis through an NGFR-Dependent Mechanism

Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.
[Nature Cancer]
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VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling

VE-cadherin was an essential scaffolding protein to maintain pro-lymphangiogenic signaling nodes at the plasma membrane, which was required for the development and adult maintenance of cardiac lymphatics, but not for cardiac function basally or after injury.
[Circulation Research]
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The RNA Helicase Ddx21 Controls Vegfc-Driven Developmental Lymphangiogenesis by Balancing Endothelial Cell Ribosome Biogenesis and p53 Function

Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation.
[Nature Cell Biology]
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REDD1 Is a Determinant of Low-Dose Metronomic Doxorubicin-Elicited Endothelial Cell Dysfunction through Downregulation of VEGFR-2/3 Expression

Researchers examined the functional role of regulated in development and DNA damage responses 1 (REDD1), an inhibitor of mammalian target of rapamycin complex 1, in low-dose metronomic chemotherapy-mediated endothelial cell dysfunction.
[Experimental and Molecular Medicine]
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MARCO+ Lymphatic Endothelial Cells Sequester Arthritogenic Alphaviruses to Limit Viremia and Viral Dissemination

Following subcutaneous inoculation, arthritogenic alphavirus particles drained via the lymph and were rapidly captured by MARCO+ lymphatic endothelial cells in the draining lymph node, limiting viral spread to the bloodstream.
[EMBO Journal]
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Corneal Lymphangiogenesis in Dry Eye Disease Is Regulated by Substance P/Neurokinin-1 Receptor System through Controlling Expression of Vascular Endothelial Growth Factor Receptor 3

Immunocytochemistry, angiogenesis assay, and western blot analysis of human dermal lymphatic endothelial cells were conducted to assess the involvement of substance P/neurokinin-1 receptor system in lymphangiogenesis.
[Ocular Surface]
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Characterization and Visualization of Murine Coagulation Factor VIII-Producing Cells In Vivo

Researchers characterized primary FVIII-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein was expressed instead of the F8 gene.
[Scientific Reports]
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L-SIGN Is a Receptor on Liver Sinusoidal Endothelial Cells for SARS-CoV-2 Virus

Scientists found that L-SIGN was highly expressed on human liver sinusoidal endothelial cells and lymph node lymphatic endothelial cells but not on blood endothelial cells.
[JCI Insight]
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Visceral Obesity and Insulin Resistance Associate with CD36 Deletion in Lymphatic Endothelial Cells

Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.
[Nature Communications]
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In Sickness and in Health: The Immunological Roles of the Lymphatic System

The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution.
[International Journal of Molecular Sciences]
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Transcription Factor FOXP2 Is a Flow-Induced Regulator of Collecting Lymphatic Vessels

Through transcriptional analysis of murine dermal lymphatic endothelial cells, scientists identified Foxp2, a member of the FOXP family of transcription factors implicated in speech development, as a collecting vessel signature gene.
[EMBO Journal]
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