lymphatic endothelial cells

[Scientific Reports] The authors found that communication network factor 2 (CCN2) induced phosphorylation of ERK in primary cultured lymphatic endothelial cells, which was almost completely inhibited by the blockade of integrin αvβ5 and partially decreased by the blockade of integrin αvβ3.

[Nature Cancer] Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.

[Circulation Research] VE-cadherin was an essential scaffolding protein to maintain pro-lymphangiogenic signaling nodes at the plasma membrane, which was required for the development and adult maintenance of cardiac lymphatics, but not for cardiac function basally or after injury.

[Nature Cell Biology] Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation.

[Experimental and Molecular Medicine] Researchers examined the functional role of regulated in development and DNA damage responses 1 (REDD1), an inhibitor of mammalian target of rapamycin complex 1, in low-dose metronomic chemotherapy-mediated endothelial cell dysfunction.

[EMBO Journal] Following subcutaneous inoculation, arthritogenic alphavirus particles drained via the lymph and were rapidly captured by MARCO+ lymphatic endothelial cells in the draining lymph node, limiting viral spread to the bloodstream.