Visceral Obesity and Insulin Resistance Associate with CD36 Deletion in Lymphatic Endothelial Cells

Investigators showed that that intestinal lymphatic endothelial cells (LECs) have an increasing CD36 expression from lymphatic capillaries to collecting vessels, and that LEC CD36 regulated lymphatic integrity and optimized lipid transport.
[Nature Communications]
Cifarelli, V., Appak-Baskoy, S., Peche, V. S., Kluzak, A., Shew, T., Narendran, R., Pietka, K. M., Cella, M., Walls, C. W., Czepielewski, R., Ivanov, S., Randolph, G. J., Augustin, H. G., & Abumrad, N. A. (2021). Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells. Nature Communications, 12(1), 3350. https://doi.org/10.1038/s41467-021-23808-3 Cite
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In Sickness and in Health: The Immunological Roles of the Lymphatic System

The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution.
[International Journal of Molecular Sciences]
Johnson, L. A. (2021). In Sickness and in Health: The Immunological Roles of the Lymphatic System. International Journal of Molecular Sciences, 22(9), 4458. https://doi.org/10.3390/ijms22094458 Cite
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Transcription Factor FOXP2 Is a Flow-Induced Regulator of Collecting Lymphatic Vessels

Through transcriptional analysis of murine dermal lymphatic endothelial cells, scientists identified Foxp2, a member of the FOXP family of transcription factors implicated in speech development, as a collecting vessel signature gene.
[EMBO Journal]
Hernández Vásquez, M. N., Ulvmar, M. H., González-Loyola, A., Kritikos, I., Sun, Y., He, L., Halin, C., Petrova, T. V., & Mäkinen, T. (2021). Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. The EMBO Journal, n/a(n/a), e107192. https://doi.org/10.15252/embj.2020107192 Cite
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Isolation and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Researchers found that lymphangioleiomyomatosi – affected lung tissues (LAM-LECs) had significantly higher ability of proliferation and migration compared to control LECs.
[Scientific Reports]
Nishino, K., Yoshimatsu, Y., Muramatsu, T., Sekimoto, Y., Mitani, K., Kobayashi, E., Okamoto, S., Ebana, H., Okada, Y., Kurihara, M., Suzuki, K., Inazawa, J., Takahashi, K., Watabe, T., & Seyama, K. (2021). Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. Scientific Reports, 11(1), 8406. https://doi.org/10.1038/s41598-021-88064-3 Cite
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GPR182 Is an Endothelium-Specific Atypical Chemokine Receptor That Maintains Hematopoietic Stem Cell Homeostasis

In constitutive GPR182-deficient mice, as well as after induced endothelium-specific loss of GPR182, investigators found significant increases in the plasma levels of CXCL10, CXCL12, and CXCL13.
[Proceedings of the National Academy of Sciences of the United States of America]
Mercier, A. L., Bonnavion, R., Yu, W., Alnouri, M. W., Ramas, S., Zhang, Y., Jäger, Y., Roquid, K. A., Jeong, H.-W., Sivaraj, K. K., Cho, H., Chen, X., Strilic, B., Sijmonsma, T., Adams, R., Schroeder, T., Rieger, M. A., & Offermanns, S. (2021). GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. Proceedings of the National Academy of Sciences, 118(17). https://doi.org/10.1073/pnas.2021596118 Cite
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Isolation and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Hhuman primary-cultured lymphatic endothelial cells were obtained both from lymphangioleiomyomatosis-affected lung tissues and normal lung tissues using fluorescence-activated cell sorting.
[Scientific Reports]
Nishino, K., Yoshimatsu, Y., Muramatsu, T., Sekimoto, Y., Mitani, K., Kobayashi, E., Okamoto, S., Ebana, H., Okada, Y., Kurihara, M., Suzuki, K., Inazawa, J., Takahashi, K., Watabe, T., & Seyama, K. (2021). Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. Scientific Reports, 11(1), 8406. https://doi.org/10.1038/s41598-021-88064-3 Cite
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Matrix Stiffness Primes Lymphatic Tube Formation Directed by Vascular Endothelial Growth Factor-C

Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).
[FASEB Journal]
Alderfer, L., Russo, E., Archilla, A., Coe, B., & Hanjaya‐Putra, D. (2021). Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C. The FASEB Journal, 35(5), e21498. https://doi.org/https://doi.org/10.1096/fj.202002426RR Cite
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PEDF Inhibits Lymphatic Metastasis of Nasopharyngeal Carcinoma as a New Lymphangiogenesis Inhibitor

Mechanistically, pigment epithelium-derived factor (PEDF) inhibited the proliferation, migration, and tube formation of lymphatic endothelial cells and promotes cell apoptosis.
[Cell Death & Disease]
Luo, C., Yin, H., Gao, T., Ma, C., Liu, J., Zhang, T., Xu, Z., Wang, X., Zhang, D., Qi, W., Yang, Z., Gao, G., Yang, X., & Zhou, T. (2021). PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03583-1 Cite
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Semaphorin3E-PlexinD1 Signaling in Coronary Artery and Lymphatic Vessel Development with Clinical Implications in Myocardial Recovery

Investigators revealed that the epicardium and pericardium-derived Semaphorin 3E and its receptor, PlexinD1, played a role in the development of the coronary stem, as well as cardiac lymphatic vessels.
[iScience]
Maruyama, K., Naemura, K., Arima, Y., Uchijima, Y., Nagao, H., Yoshihara, K., Singh, M. K., Uemura, A., Matsuzaki, F., Yoshida, Y., Kurihara, Y., Miyagawa-Tomita, S., & Kurihara, H. (2021). Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102305 Cite
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SUMOylation Promotes Extracellular Vesicle-Mediated Transmission of lncRNA ELNAT1 and Lymph Node Metastasis in Bladder Cancer

The authors identified that bladder cancer (BCa) cell-secreted extracellular vesicles mediated the intercellular communication with human lymphatic endothelial cells through the transmission of a long noncoding RNA ELNAT1, and promoted lymphangiogenesis and LN metastasis in a SUMOylation-dependent manner in both cultured BCa cell lines and mouse models.
[Journal of Clinical Investigation]
Chen, C., Zheng, H., Luo, Y., Kong, Y., An, M., Li, Y., He, W., Gao, B., Zhao, Y., Huang, H., Huang, J., & Lin, T. (2021). SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI146431 Cite
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Mesenchymal Stem Cell Exosome-Derived miR-223 Alleviates Acute Graft-versus-Host Disease via Reducing the Migration of Donor T Cells

Investigators performed expression profiling of exosome-miRNAs from human umbilical cord mesenchymal stem cells (MSCs) and murine compact bone MSCs to investigate their immunoregulation effects in acute graft-versus-host disease.
[Stem Cell Research & Therapy]
Liu, W., Zhou, N., Liu, Y., Zhang, W., Li, X., Wang, Y., Zheng, R., & Zhang, Y. (2021). Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells. Stem Cell Research & Therapy, 12(1), 153. https://doi.org/10.1186/s13287-021-02159-2 Cite
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