lymphatic endothelial cells

[Scientific Reports] Researchers found that lymphangioleiomyomatosi - affected lung tissues (LAM-LECs) had significantly higher ability of proliferation and migration compared to control LECs.

[Proceedings of the National Academy of Sciences of the United States of America] In constitutive GPR182-deficient mice, as well as after induced endothelium-specific loss of GPR182, investigators found significant increases in the plasma levels of CXCL10, CXCL12, and CXCL13.

[Scientific Reports] Hhuman primary-cultured lymphatic endothelial cells were obtained both from lymphangioleiomyomatosis-affected lung tissues and normal lung tissues using fluorescence-activated cell sorting.

[FASEB Journal] Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C (VEGF‐C).

[Cell Death & Disease] Mechanistically, pigment epithelium-derived factor (PEDF) inhibited the proliferation, migration, and tube formation of lymphatic endothelial cells and promotes cell apoptosis.

[iScience] Investigators revealed that the epicardium and pericardium-derived Semaphorin 3E and its receptor, PlexinD1, played a role in the development of the coronary stem, as well as cardiac lymphatic vessels.